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    1. Structural Biology and Molecular Biophysics

    The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism

    Jessica J Stanisich, Dawid S Zyla ... Rudi Glockshuber
    Cryo-EM reveals that an unexpected domain separation in the zona pellucida module of uromodulin is required for its assembly to filamentous homopolymers that promote pathogen clearance in urinary tract infections.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin

    Martina Brunati, Simone Perucca ... Luca Rampoldi
    Hepsin is the first protease identified to modulate specific cleavage and secretion of a Zona Pellucida domain protein, uromodulin.
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