The use of liquid-infused catheters results in significant reduction of bladder and catheter colonization, systemic dissemination, and bladder inflammation in a clinically relevant mouse model of CAUTI by targeting host-protein deposition on the urinary catheter.

Conserved transcriptomic profile of uropathogenic E. coli in patients identifies an infection-specific metabolic state.

By binding with their type 1 pili to the cell surface receptor CD14, pathogenic E. coli suppress the capacity of dendritic cells to activate T cells.

Live-cell imaging captures the heterogenity of bacterial growth within intracellular bacterial communities and demonstrates that the constituent bacteria are protected from clearance by antibiotics delivered with a physiologically relevant pharmacodynamic profile.

Cryo-EM reveals that an unexpected domain separation in the zona pellucida module of uromodulin is required for its assembly to filamentous homopolymers that promote pathogen clearance in urinary tract infections.

Input from computational models has enabled the detection of allosteric communication that modulates the gating mechanism of a bacterial outer-membrane protein.

E. coli that cause neonatal meningitis largely derive from two global clonal lineages that can additionally form intestinal reservoirs to seed recrudescent invasive infection even when appropriate antibiotics are used.

A strategical positioning of resident immune cells are key in determining a tightly controlled immune environment in the different regions of the mouse epididymis that creates unique spatial milieus for sperm maturation and combatting invading pathogens.

The helical rod structure and dynamic spring-like properties of the type 1 pilus are evolutionarily fine-tuned for functioning in host-pathogen interactions during urinary tract infection and gut colonization.

Polarizing susceptibilities to recurrent bladder infection are shaped by a duality in TNFɑ-mediated inflammation dynamics upon challenge infection that is dictated by the outcome of the initial infection.