LncRNA-Snhg3 regulates lipid metabolism by affecting chromatin accessibility which indicates that lncRNA-mediated epigenetic modification has a crucial role in the pathology of metabolic dysfunction-associated fatty liver disease.

Neuron-specific sequencing of aged wild-type, daf-2, and daf-16;daf-2 mutants revealed transcriptomic changes with age, and in longevity mutants, putative neuroprotective genes are upregulated, which are required for prolonged cognitive functions.

Genetic and biochemical analysis reveals that the anti-inflammatory effect of statins is due to decreasing cholesterol in macrophages and upregulating Jmjd3 to achieve the anti-inflammatory action.

Exposure to high-sugar diet in Drosophila resulted in the suppression of sweet sensitivity and feeding behavior in the offspring via altered epigenetic modifications on the histone, highlighting sustained impact of ancestral experience on the physiology and health of offspring.

A survey of oxygen-dependent enzymes suggests new candidates for oxygen sensors, expanding potential mechanisms underlying hypoxia-related adaptations or diseases in humans.

Epigenetic regulator MLL3 is mutated and lost in human hepatocellular carcinoma due to its ability to activate a well-defined tumor suppressor and cell death in transformed cells.

Bidirectional regulation of the chromatin modification H3K27me3 orchestrates programs of gene expression that underlie postmitotic stages of neuronal maturation.

The depletion of a new class of putative histone methyltransferases, including MET-2, SET-6, SET-19, SET-20, SET-21, SET-32, and SET-33, induced synergistic lifespan extension in daf-2 animals to an average lifespan nearly three times that of wild-type animals.

The mammalian Y chromosome has become specialised for male fertility, but exact functions of individual Y genes remain poorly understood, a knowledge gap that new approaches can bridge.

Herpes simplex virus reactivates from a latent infection when neurons become hyperexcitable in response to an inflammatory cytokine known to be released during fever and stress.