1,224 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering

    Gamze Çamdere et al.
    A critical second step in DNA tethering by cohesin occurs after its stable binding to DNA, and this second step is modulated by the Smc3 ATPase active site in Saccharomyces cerevisiae.
    1. Cell Biology

    The GTPase IFT27 is involved in both anterograde and retrograde intraflagellar transport

    Diego Huet et al.
    A small GTPase within the flagellum can participate in the control of transport from the base to the tip of the flagellum, and back again.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases

    Han Han et al.
    Structural and biochemical studies indicate that AAA+ ATPase employ a general mechanism to translocate a variety of substrates, including extended polypeptides, hairpins, crosslinked chains, and chains conjugated to other molecules.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels

    Anna L Miles et al.
    An unbiased genome-wide human forward genetic screen identifies the vacuolar ATPase complex and assembly factors as regulators of HIF stability through their actions on intracellular iron metabolism.
    1. Biochemistry and Chemical Biology

    DNA polymerase V activity is autoregulated by a novel intrinsic DNA-dependent ATPase

    Aysen L Erdem et al.
    DNA synthesis by DNA polymerase V is regulated by an intrinsic DNA-dependent ATPase activity which has not been observed for any other polymerase.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Structure of the active form of human origin recognition complex and its ATPase motor module

    Ante Tocilj et al.
    The human Origin Replication Complex is shaped as a shallow corkscrew in a classic AAA+ organization reminiscent of clamp loader complexes with highly controlled ATPase activity as exemplified by Meier-Gorlin syndrome mutations.
    1. Cell Biology

    The yeast H+-ATPase Pma1 promotes Rag/Gtr-dependent TORC1 activation in response to H+-coupled nutrient uptake

    Elie Saliba et al.
    The H+ influx coupled to nutrient uptake and the plasma membrane H+-ATPase are central actors of the activation of target of rapamycin complex 1 (TORC1) in budding yeast Saccharomyces cerevisiae..
    1. Cell Biology
    2. Developmental Biology

    CasExpress reveals widespread and diverse patterns of cell survival of caspase-3 activation during development in vivo

    Austin Xun Ding et al.
    Genetic labeling of cells that survive executioner caspase activity in Drosophila reveals distinct patterns in different tissues.
    1. Structural Biology and Molecular Biophysics

    Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites

    Baoyu Chen et al.
    The cryo-electron microscopy structure of an assembly of the WAVE Regulatory Complex and its activator, the Rac GTPase, plus complementary biochemistry and biophysics, reveal a novel activation mechanism involving two distinct Rac binding sites.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural and biochemical analyses of the DEAD-box ATPase Sub2 in association with THO or Yra1

    Yi Ren et al.
    Biochemical and structural analyses of a universal mRNP remodeling pathway suggest an ATPase-powered targeted deposition of export factors onto mRNP.

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