1,752 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases

    Han Han et al.
    Structural and biochemical studies indicate that AAA+ ATPase employ a general mechanism to translocate a variety of substrates, including extended polypeptides, hairpins, crosslinked chains, and chains conjugated to other molecules.
    1. Structural Biology and Molecular Biophysics

    Mechanical inhibition of isolated Vo from V/A-ATPase for proton conductance

    Jun-ichi Kishikawa et al.
    Cryo-EM structures of rotary V-ATPase reveal the ON-OFF switching mechanism of H+ translocation in the Vo membrane domain.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering

    Gamze Çamdere et al.
    A critical second step in DNA tethering by cohesin occurs after its stable binding to DNA, and this second step is modulated by the Smc3 ATPase active site in Saccharomyces cerevisiae.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels

    Anna L Miles et al.
    An unbiased genome-wide human forward genetic screen identifies the vacuolar ATPase complex and assembly factors as regulators of HIF stability through their actions on intracellular iron metabolism.
    1. Cell Biology
    2. Developmental Biology

    CasExpress reveals widespread and diverse patterns of cell survival of caspase-3 activation during development in vivo

    Austin Xun Ding et al.
    Genetic labeling of cells that survive executioner caspase activity in Drosophila reveals distinct patterns in different tissues.
    1. Cancer Biology

    Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis

    Ian M Cartwright et al.
    Myc expression is shown to cause sublethal activation of Caspase-3 and downstream endonuclease G, which causes DNA double strand breaks and oncogenic transformation in human cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    ATPase activity of the DEAD-box protein Dhh1 controls processing body formation

    Christopher Frederick Mugler et al.
    The ATPase Dhh1 controls processing body formation and disassembly in yeast cells, and processing body dynamics can be recapitulated in vitro with recombinant Dhh1, ATP and RNA.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A putative ATPase mediates RNA transcription and capping in a dsRNA virus

    Xuekui Yu et al.
    Atomic structures suggest a novel mechanism for the regulation of mRNA transcription and capping in dsRNA viruses.
    1. Biochemistry and Chemical Biology

    The GTPase Nog1 co-ordinates the assembly, maturation and quality control of distant ribosomal functional centers

    Purnima Klingauf-Nerurkar et al.
    The GTPase Nog1 orchestrates stalk assembly, peptidyl transferase centre maturation and polypeptide exit tunnel quality control.
    1. Plant Biology

    The Arabidopsis V-ATPase is localized to the TGN/EE via a seed plant-specific motif

    Upendo Lupanga et al.
    Analysis of the Arabidopsis V-ATPase reveals convergent evolution of differential targeting as well as redundancy of the endosomal and vacuolar isoforms during vegetative development.

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