Whole-brain quantitative input-output circuits of glutamatergic and GABAergic neurons in the mouse dorsal and median raphe nuclei were mapped using viral tracing and high-resolution optical imaging.
Francois M Lambert, Laura Cardoit ... Didier Le Ray
Molecular labeling, electrophysiology and calcium imaging have revealed a novel switching of neurotransmitter at the frog neuromuscular junction where motoneurons transiently release glutamate before acetylcholine at synapses on developing hindlimb muscles at the onset of metamorphosis.
A combination of physiological, histological, and optical approaches reveals synapse-specific function of α-synuclein in mouse brain under both normal and pathological states.
Retrograde tracing of the neural circuits that control movement of the jaw and tongue reveals how shared premotor neurons help to ensure coordinated muscle activity.
Exogenous opioid analgesia is mediated by MORs expressed in glutamatergic neurons, whereas endogenous opioid analgesia is mediated by MORs expressed in GABAergic neurons.
An unbiased transcriptomic approach reveals that developing paddlefish electrosensory organs express genes essential for mechanosensory hair cell development and synaptic transmission, and identifies candidates for mediating electroreceptor development and function.
Isabella Farhy-Tselnicker, Matthew M Boisvert ... Nicola J Allen
RNA sequencing and genetic mouse models reveal that transcriptional changes to astrocytes in the developing cortex are not intrinsic but influenced by their environment and determine that expression of astrocyte synapse-regulating genes and neuronal synaptogenesis is modulated by ongoing astrocyte-neuron communication.
Co-release of the functionally opposing fast neurotransmitters, glutamate and GABA, from distinct synaptic vesicles within the same supramammillary synaptic terminal modulates dentate granule cell firing in a frequency-dependent manner.
