283 results found
    1. Immunology and Inflammation

    Resident macrophages acquire innate immune memory in staphylococcal skin infection

    Reinhild Feuerstein, Aaron James Forde ... Philipp Henneke
    Resident dermal Mφ are programmed locally, independently of bone-marrow monocytes during Staphylococcus aureus infection, leading to transiently increased resistance, which is limited by a decrease in macrophage life span.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity

    Margaret A Myers, Amanda P Smith ... Amber M Smith
    Important nonlinear links between infection, inflammation, and disease severity were revealed using experimentally validated mathematical models.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus

    Yuting Zhang, Min Zhang ... Guojiang Chen
    A novel antibody recognizing receptor-binding region of MARV glycoprotein was developed and displays broad-spectrum neutralizing activity to filovirus species when NPC2 was fused to the N-terminus of the mAb.
    1. Cell Biology

    The relative binding position of Nck and Grb2 adaptors impacts actin-based motility of Vaccinia virus

    Angika Basant, Michael Way
    The ability of Vaccinia virus to induce actin polymerisation depends on the relative binding position of adaptors within the signalling network activating the Arp2/3 complex.
    1. Immunology and Inflammation

    Overriding impaired FPR chemotaxis signaling in diabetic neutrophil stimulates infection control in murine diabetic wound

    Ruchi Roy, Janet Zayas ... Sasha H Shafikhani
    Therapeutic potential of CCL3 for the treatment of diabetic foot ulcers if it is applied topically after the surgical debridement.
    1. Medicine
    2. Microbiology and Infectious Disease

    The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2

    Hsiao-Fan Chen, Wei-Jan Wang ... Mien-Chie Hung
    Two natural tannins, oligomeric proanthocyanidins and punicalagin, acted as potent inhibitors against SARS-CoV-2 infection, and grape seed extract supplementation could serve as a healthy food for infection prevention.
    1. Epidemiology and Global Health

    Science Forum: Adding a One Health approach to a research framework for minority health and health disparities

    Brittany L Morgan, Mariana C Stern ... Laura Fejerman
    Adding a One Health approach to a research framework for minority health and health disparities encourages the exploration of new avenues of inquiry, multidisciplinary collaboration, and the consideration of new determinants of health.
    1. Structural Biology and Molecular Biophysics

    All-atom molecular dynamics of the HBV capsid reveals insights into biological function and cryo-EM resolution limits

    Jodi A Hadden, Juan R Perilla ... Klaus Schulten
    All-atom molecular dynamics of the HBV capsid supports a role for structural asymmetry in biological function, reveals the potential for triangular pores to mediate cellular signaling, and indicates that capsid flexibility may limit resolution attainable by cryo-EM.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Cytotoxic activities of CD8+ T cells collaborate with macrophages to protect against blood-stage murine malaria

    Takashi Imai, Hidekazu Ishida ... Hajime Hisaeda
    The cytotoxicity exerted by CD8+ T cells against parasitized erythroblasts helps to protect against blood-stage malaria by making parasitized cells susceptible to phagocytosis.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Epidemiological dynamics of Ebola outbreaks

    Thomas House
    The pattern of past Ebola outbreaks is indicative of an effective reproductive ratio of less than 1, which can lead to the generation of a range of outbreak sizes consistent with the scale of the ongoing epidemic.

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