2,101 results found
    1. Structural Biology and Molecular Biophysics

    N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2

    Fang Tian et al.
    Spike protein of SARS-CoV-2 with mutation N501Y shows a faster association rate, slower dissociation rate, and higher binding probability and unbinding force to its human receptor protein ACE2, leading to higher transmission.
    1. Medicine

    Aorta smooth muscle-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease

    Mieradilijiang Abudupataer et al.
    An aorta smooth muscle-on-a-chip model indicated that NOTCH1 insufficiency in HAoSMCs induced phenotypic switching from a contractile to a synthetic phenotype accompanied by an impairment of mitochondrial fusion, implying its potential role as a therapeutic target for BAV-TAA.
    1. Cell Biology
    2. Neuroscience

    Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration

    Rene Solano Fonseca et al.
    Promoting a Warburg-like shift in astrocytic metabolism through reduced mitochondrial electron transport accommodates the energetic burden caused by brain trauma without overwhelming cellular respiration and redox to salvage dopaminergic neurons.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Characterizing human mobility patterns in rural settings of sub-Saharan Africa

    Hannah R Meredith et al.
    Mobile phone data reveal aspects of human mobility patterns in Sub-Saharan Africa missed by standard spatial models however, model estimates can be improved by accounting for trip urbanicity and region.
    1. Computational and Systems Biology

    PARROT is a flexible recurrent neural network framework for analysis of large protein datasets

    Daniel Griffith, Alex S Holehouse
    PARROT makes it easy for anyone to train and use system- or data-specific deep learning models that map between protein sequence and arbitrary sequence annotations.
    1. Immunology and Inflammation

    Ascorbic acid supports ex vivo generation of plasmacytoid dendritic cells from circulating hematopoietic stem cells

    Anders Laustsen et al.
    Probing of various culture conditions leads to fundamental advances in ex vivo production of plasmacytoid dendritic cells for use in immunotherapy.
  1. Annual Report: 2020 in review

    We reflect on eLife’s efforts to drive change in scientific and medical publishing during an eventful year.
    1. Developmental Biology
    2. Neuroscience

    The development of active binocular vision under normal and alternate rearing conditions

    Lukas Klimmasch et al.
    A new computational model explains how alternate rearing conditions affect the development of binocular vision.
    1. Neuroscience

    Classification and genetic targeting of cell types in the primary taste and premotor center of the adult Drosophila brain

    Gabriella R Sterne et al.
    A split-GAL4 collection provides precise genetic targeting of 138 neuronal cell types in the subesophageal zone of adult Drosophila melanogaster.

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