1,267 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    An integrin/MFG-E8 shuttle loads HIV-1 viral-like particles onto follicular dendritic cells in mouse lymph node

    Chung Park, John H Kehrl
    Intravital imaging with HIV-1 viral-like particle in mouse model reveals a mechanism for HIV-1 uptake by subcapsular sinus macrophages that facilitates HIV-1 spreading tofollicular dendritic and B cells.
    1. Neuroscience

    One-shot learning and behavioral eligibility traces in sequential decision making

    Marco P Lehmann et al.
    Human learning relies on short-term memories (eligibility traces) which provide a mechanism to reinforce sequences of actions from a single reward (one-shot).
    1. Neuroscience

    DeepPoseKit, a software toolkit for fast and robust animal pose estimation using deep learning

    Jacob M Graving et al.
    A new deep-learning software toolkit with general-purpose methods for quickly and reliably measuring the full body posture of animals directly from images or videos without physical markers.
    1. Structural Biology and Molecular Biophysics

    The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels

    Alessandro Porro et al.
    Experimental and computational approaches reveal how ligand binding is coupled to voltage sensing in a HCN channels.
    1. Neuroscience

    High-throughput microcircuit analysis of individual human brains through next-generation multineuron patch-clamp

    Yangfan Peng et al.
    Combining a multineuron patch-clamp system with an automated pipette pressure and cleaning device enables efficient screening of synaptic connectivity in human brain slices and allows inter-individual comparison.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Initiation of chromosome replication controls both division and replication cycles in E. coli through a double-adder mechanism

    Guillaume Witz et al.
    Single-cell measurements combined with a new statistical framework for discriminating between models of cell cycle regulation show that chromosome initiation controls the E. coli cell cycle via two adder mechanisms.
    1. Ecology

    Biophysical and physiological processes causing oxygen loss from coral reefs

    Cynthia B Silveira et al.
    Coral reef heterotrophic bacteria and fleshy macroalgae cause oxygen loss from reef systems through microbial biomass accumulation and ebullition from algae surfaces.
    1. Neuroscience
    2. Physics of Living Systems

    Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia

    Andrew R McKinstry-Wu et al.
    Responses to anesthetics differ among individuals and fluctuate stochastically despite constant drug concentration, however, the amount of noise driving transitions between the responsive and the unresponsive state is conserved.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Formation of a β-barrel membrane protein is catalyzed by the interior surface of the assembly machine protein BamA

    James Lee et al.
    Outer membrane β-barrel proteins in Gram-negative bacteria are assembled within the lumen of the BamA β-barrel.
    1. Chromosomes and Gene Expression

    An mRNA-binding channel in the ES6S region of the translation 48S-PIC promotes RNA unwinding and scanning

    Irene Díaz-López et al.
    The ES6S region of the small subunit ribosome makes a place for the threading and secondary structure unwinding of mRNA, which regulates genome-wide translation.

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