Type I IFN is a key determinant of pathogenic neutrophil activity and drives tissue pathology through modulation of IL-18 levels during genital HSV infection.
Satvika Burugupalli, Adam Alexander T Smith ... Barwon Infant Study Investigator team
Plasma lipidomic profiling in pregnancy, infancy and early childhood provides a framework to define the relationship between lipid metabolism and health outcomes in early childhood.
Michael Garratt, Ilkim Erturk ... Richard A Miller
Early-life exposure to conspecific urine and bedding extends the lifespan of female mice, indicating that social chemosensory cues can influence aging in a mammal.
Mucosal application of the anti-retroviral drug tenofovir, which is intended to prevent HIV transmission, has many off-target effects on the mucosa itself.
Andrés Aranda-Díaz, Benjamin Obadia ... Kerwyn Casey Huang
Shifts in pH that result from metabolic interactions between members of the Drosophila gut microbiota were sufficient to modulate Lactobacillus plantarum tolerance to the antibiotics rifampin and erythromycin.
Annamarie E Bustion, Renuka R Nayak ... Katherine S Pollard
Computational reaction representations and profile hidden Markov model searches of metagenomics databases can be harnessed to accurately predict bacterial species and enzyme sequences responsible for biotransformations in the human gut microbiome.
Alison M Devault, Tatum D Mortimer ... Caitlin S Pepperell
Mineralized placental tissue from Late Byzantine Troy enables the detailed reconstruction of genomes of mixed bacterial species responsible for maternal sepsis in the ancient world.
The immune system in the vagina becomes more active when young women begin to have sexual intercourse, and this immune activity could influence the risk of acquiring sexually transmitted infections.
