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    1. Ecology

    Global warming reduces leaf-out and flowering synchrony among individuals

    Constantin M Zohner, Lidong Mo, Susanne S Renner
    Individuals differ in how their leaf-out and flowering are regulated by abiotic stimuli and, under climate warming, this leads to reduced within-population phenological synchrony, impacting mutualistic and antagonistic community interactions.
    1. Cell Biology
    2. Developmental Biology

    A new mode of pancreatic islet innervation revealed by live imaging in zebrafish

    Yu Hsuan Carol Yang, Koichi Kawakami, Didier YR Stainier
    A novel mode of organ innervation, whereby neurons establish connections with their targets before migrating away, was revealed by live imaging of the developing zebrafish pancreas.
    1. Biochemistry and Chemical Biology

    Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

    Nicole L Jenkins, Simon A James ... Gawain McColl
    As worms age reduced glutathione together with increased ferrous iron increases frailty and leads to ferroptosis, which is amenable to therapeutic intervention.
    1. Neuroscience

    Live calcium and mitochondrial imaging in the enteric nervous system of Parkinson patients and controls

    An-Sofie Desmet, Carla Cirillo ... Pieter Vanden Berghe
    In contrast to previous post-mortem or fixed tissue histochemical reports, live calcium and mitochondrial imaging data suggest that the enteric nervous system is not generally affected in Parkinson's disease patients.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Philosophy of Biology: The meanings of 'function' in biology and the problematic case of de novo gene emergence

    Diane Marie Keeling, Patricia Garza ... Anne-Ruxandra Carvunis
    A lexicon to help scientists and philosophers discuss the meaning of function in molecular biology more clearly is proposed.
    1. Medicine

    Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer

    Yixiao Zhang, Lisha Sun ... Caigang Liu
    The upregulation of TLN1 contributes to the metastasis of triple-negative breast cancer (TNBC), and a small-molecule C67399 was screened for blocking TLN1 and integrin β1 may hold promise for the treatment of TNBC.
    1. Neuroscience

    Synaptic up-scaling preserves motor circuit output after chronic, natural inactivity

    Joseph M Santin, Mauricio Vallejo, Lynn K Hartzler
    Synaptic scaling maintains motor output from the respiratory network of bullfrogs after months of inactivity in the winter, providing evidence for homeostatic plasticity in response to large ecologically relevant perturbations in neuronal activity.
    1. Neuroscience

    Role of the postinspiratory complex in regulating swallow–breathing coordination and other laryngeal behaviors

    Alyssa Huff, Marlusa Karlen-Amarante ... Jan-Marino Ramirez
    The postinspiratory complex acts as an interface between the swallow pattern generator and the preBötzinger complex to coordinate swallow and breathing.
    1. Developmental Biology
    2. Neuroscience

    MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons

    Caitlin Engelhard, Sarah Sarsfield ... David D Ginty
    A protein called Megf8 regulates the activity of key signaling molecules involved in the development of the peripheral nervous system.
    1. Neuroscience

    The shared and unique neural correlates of personal semantic, general semantic, and episodic memory

    Annick FN Tanguay, Daniela J Palombo ... Louis Renoult
    Four types of declarative memory rely on different weightings of similar component processes, according to fMRI and subjective ratings.