4,719 results found
    1. Cell Biology

    The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis

    Philipp Kimmig, Marcy Diaz ... Peter Walter
    A unique form of regulation has been observed in the unfolded protein response of S. pombe, along with a novel mechanism of post-transcriptional mRNA processing.
    1. Structural Biology and Molecular Biophysics

    Molecular architecture of human polycomb repressive complex 2

    Claudio Ciferri, Gabriel C Lander ... Eva Nogales
    Electron microscopy has been used to produce the first three-dimensional image of the PRC2 gene-silencing complex.
    1. Neuroscience

    Foggy perception slows us down

    Paolo Pretto, Jean-Pierre Bresciani ... Heinrich H Bülthoff
    Virtual reality experiments show that motorists slow down when driving in fog, but they speed up when visibility is reduced equally at all distances.
    1. Biochemistry and Chemical Biology

    Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics

    Syed M Moin, Sinisa Urban
    Intramembrane proteases identify target proteins in a different way from other proteases.
    1. Neuroscience

    The activity-dependent histone variant H2BE modulates the life span of olfactory neurons

    Stephen W Santoro, Catherine Dulac
    A genome-organizing protein that is present only in the olfactory system of mice has been found to orchestrate changes in the relative numbers of different odor-sensing neurons on the basis of how active these neurons are.
    1. Structural Biology and Molecular Biophysics

    Modelling dynamics in protein crystal structures by ensemble refinement

    B Tom Burnley, Pavel V Afonine ... Piet Gros
    A combination of molecular dynamics simulations and X-ray diffraction data has been used to construct more realistic models of proteins and to provide new insights into their interactions with other proteins and biomolecules.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

    Anca M Farcas, Neil P Blackledge ... Robert J Klose
    A protein that can recognize regions of DNA with a high proportion of unmethylated CpG dinucleotides, and then recruit polycomb group proteins to these CpG islands, has been identified.
    1. Neuroscience

    Quantification of gait parameters in freely walking wild type and sensory deprived Drosophila melanogaster

    César S Mendes, Imre Bartos ... Richard S Mann
    Novel imaging experiments suggest that fruit flies modify their neural circuitry for walking at slow, medium and fast speeds, and that proprioception is not essential for coordinated walking.
    1. Neuroscience

    Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo

    Verena Pawlak, David S Greenberg ... Jason ND Kerr
    Changing the order in which presynaptic and postsynaptic cells are repeatedly activated can change what a mammalian visual cortex neuron communicates to downstream neurons.
    1. Neuroscience

    Recognition of familiar food activates feeding via an endocrine serotonin signal in Caenorhabditis elegans

    Bo-mi Song, Serge Faumont ... Leon Avery
    The nematode worm C. elegans consumes familiar bacterial species more rapidly than it does novel ones, and this preference for familiarity is mediated by a pair of serotonergic neurons.

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