29 results found
    1. Structural Biology and Molecular Biophysics

    The ion selectivity filter is not an activation gate in TRPV1-3 channels

    Andrés Jara-Oseguera et al.
    The TRPV1, TRPV2 and TRPV3 channels are gated on the cytosolic side of the pore, whereas structural changes in the ion selectivity filter associated with activation don't control cation access.
    1. Immunology and Inflammation
    2. Neuroscience

    Intestinal infection regulates behavior and learning via neuroendocrine signaling

    Jogender Singh, Alejandro Aballay
    Feedback from the intestine during infection can modulate the behavior, learning, and microbial perception of the host.
    1. Neuroscience

    Novel long-range inhibitory nNOS-expressing hippocampal cells

    Zoé Christenson Wick et al.
    An intersectional genetic vector approach allows the identification and characterization of novel hippocampal inhibitory neurons with both broad local connectivity within CA1 and long-range projections to several extrahippocampal areas.
    1. Structural Biology and Molecular Biophysics

    Structure-based characterization of novel TRPV5 inhibitors

    Taylor ET Hughes et al.
    Structure-based virtual screening reveals multiple novel TRPV5 inhibitors that bind and exert their effect from previously unidentified binding sites as characterized by cryo-electron microscopy and electrophysiology.
    1. Neuroscience

    Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry

    Seksiri Arttamangkul et al.
    Opioid sensitive neurons were identified using a traceless affinity labeling strategy to covalently label endogenous mu-opioid receptors with fluorescent compounds in living brain slices from wild type animals.
    1. Structural Biology and Molecular Biophysics

    Molecular mechanism of TRPV2 channel modulation by cannabidiol

    Ruth A Pumroy et al.
    Cannabidiol binds to TRPV2 via a previously unidentified, but highly conserved, pocket.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Rhodoquinone biosynthesis in C. elegans requires precursors generated by the kynurenine pathway

    Samantha Del Borrello et al.
    Parasitic helminths infect over a billion humans and use unusual anaerobic metabolism that needs a rare electron carrier, Rhodoquinone (RQ), whose synthesis requires the kynurenine pathway of tryptophan degradation.
    1. Structural Biology and Molecular Biophysics

    Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes

    Lejla Zubcevic et al.
    Ligand-induced two-fold symmetric arrangement in TRPV2 is observed in the native-like nanodisc-reconstituted condition using cryo-electron microscopy.
    1. Structural Biology and Molecular Biophysics

    Regulatory switch at the cytoplasmic interface controls TRPV channel gating

    Lejla Zubcevic et al.
    C-terminal domain of thermoTRPV channels regulates channel gating at the cytoplasmic interface through a switch-like process.
    1. Structural Biology and Molecular Biophysics

    Automated cryo-EM structure refinement using correlation-driven molecular dynamics

    Maxim Igaev et al.
    Correlation-driven molecular dynamics provides a fully automated and human-bias-free framework for quantitative interpretation of modern cryo-electron microscopy data.

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