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    1. Cell Biology

    Phosphorylation of β-arrestin2 at Thr383 by MEK underlies β-arrestin-dependent activation of Erk1/2 by GPCRs

    Elisabeth Cassier et al.
    Phosphoproteomics identifies β-arrestin 2 phosphorylation at Thr383 by MEK as a key step of GPCR-induced Erk½ activation, thus providing new insight into the molecular mechanism underlying β-arrestin-dependent GPCR-operated signaling.
    1. Neuroscience

    TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro

    Hugo Balleza-Tapia et al.
    TrpV1 receptor activation rescues cognition-relevant network dynamics in mouse hippocampus in an acute Alzheimer disease model providing a novel therapeutic target.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor

    Anastasiia Stratiievska et al.
    A dual-color TIRFM study reveals a new form of inflammatory regulation, in which a lipid kinase and ion channel reciprocally regulate each other to amplify the response to painful stimuli.
    1. Biochemistry and Chemical Biology

    Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

    Matthijs Kol et al.
    Photoswitchable ceramides containing an azobenzene photoswitch behave as light-controllable substrates for both sphingomyelin synthase and glucosylceramide synthase.
    1. Structural Biology and Molecular Biophysics

    Regulatory switch at the cytoplasmic interface controls TRPV channel gating

    Lejla Zubcevic et al.
    C-terminal domain of thermoTRPV channels regulates channel gating at the cytoplasmic interface through a switch-like process.
    1. Neuroscience
    2. Physics of Living Systems

    Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure

    Simon Bulley et al.
    Arterial myocyte PKD2 channels are activated by vasoconstrictor stimuli, which increases blood pressure, are upregulated during hypertension and cell-specific knockout in vivo reduces both physiological blood pressure and hypertension.
    1. Structural Biology and Molecular Biophysics

    Structure-based characterization of novel TRPV5 inhibitors

    Taylor ET Hughes et al.
    Structure-based virtual screening reveals multiple novel TRPV5 inhibitors that bind and exert their effect from previously unidentified binding sites as characterized by cryo-electron microscopy and electrophysiology.
    1. Immunology and Inflammation
    2. Neuroscience

    Intestinal infection regulates behavior and learning via neuroendocrine signaling

    Jogender Singh, Alejandro Aballay
    Feedback from the intestine during infection can modulate the behavior, learning, and microbial perception of the host.
    1. Plant Biology

    Auxin production in the endosperm drives seed coat development in Arabidopsis

    Duarte D Figueiredo et al.
    Auxin is produced in the endosperm after fertilization and drives the development of the seed coat in Arabidopsis.
    1. Structural Biology and Molecular Biophysics

    An external sodium ion binding site controls allosteric gating in TRPV1 channels

    Andres Jara-Oseguera et al.
    Allosteric gating in a transient receptor potential channel is modulated by external sodium ions and a tarantula toxin.