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    1. Ecology
    2. Genetics and Genomics

    The Natural History of Model Organisms: The fascinating and secret wild life of the budding yeast S. cerevisiae

    Gianni Liti
    The yeast Saccharomyces cerevisiae has informed our understanding of molecular biology and genetics for decades, and learning more about its natural history could fuel a new era of functional and evolutionary studies of this classic model organism.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Fossils: A new home for microbes

    Raphael Eisenhofer, Alan Cooper
    Modern microorganisms growing in fossils provide major challenges for researchers trying to detect ancient molecules in the same fossils.
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    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Cutting Edge: Building bridges between cellular and molecular structural biology

    Ardan Patwardhan et al.
    The integration of structural data from different imaging scales requires the development of standards and tools for representing the segmentation and transformation of data, and for the annotation of biological structures.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Science Forum: Viral factors in influenza pandemic risk assessment

    Marc Lipsitch et al.
    We identify key strengths and limitations in use of viral genotyping and phenotyping to estimate pandemic risk from influenza A viruses, focusing on 3 traits, hemagglutinin binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency.
    1. Microbiology and Infectious Disease
    2. Ecology

    The Natural History of Model Organisms: The unexhausted potential of E. coli

    Zachary D Blount
    A better understanding of the remarkable diversity, natural history and complex ecology of E. coli in the wild could shed new light on its biology and role in disease, and further expand its many uses as a model organism.
    1. Genetics and Genomics

    Science Forum: The single-cell eQTLGen consortium

    MGP van der Wijst et al.
    The single-cell eQTLGen consortium aims to pinpoint the cellular contexts in which disease-causing genetic variants affect gene expression and its regulation.
    1. Biochemistry and Chemical Biology

    Science Forum: Donated chemical probes for open science

    Susanne Müller et al.
    A collaboration between several pharmaceutical companies provides a unique resource of high-quality chemical probes and associated data from the companies to the academic community.
    1. Computational and Systems Biology

    Research: Bias in the reporting of sex and age in biomedical research on mouse models

    Oscar Flórez-Vargas et al.
    A text-mining study suggests that about half of the papers reporting the results of experiments on mice do not report the sex and age of the mice.
    1. Human Biology and Medicine

    Science Forum: RIPOSTE: a framework for improving the design and analysis of laboratory-based research

    Nicholas GD Masca et al.
    The RIPOSTE framework has been developed to support early and regular discussions between scientists and statisticians in order to improve the design, conduct and analysis of laboratory studies.
    1. Microbiology and Infectious Disease

    Homeostatic control of cell wall hydrolysis by the WalRK two-component signaling pathway in Bacillus subtilis

    Genevieve S Dobihal et al.
    Molecular genetic analyses define the first homeostatic control pathway that maintains cell wall remodeling activity during bacterial growth.