Téo Fournier, Omar Abou Saada ... Joseph Schacherer
Genome-wide association studies on a diallel yeast panel revealed the relevance of low-frequency variants on the phenotypic diversity and consequently on the missing heritability at a population-scale.
Natalia Felipe-Medina, Sandrine Caburet ... Alberto M Pendás
Genetic and biochemical analysis reveal a variant in HSF2BP causing POI and C19ORF57/BRME1 as an interactor and stabilizer of HSF2BP by forming a complex with BRCA2, RAD51, RPA and PALB2.
Carinna Hockham, Supachai Ekwattanakit ... Frédéric B Piel
The incorporation of as yet underused local epidemiological data on α-thalassaemia in Southeast Asia within a geostatistical model suggests that the burden of severe α-thalassaemia forms may have been underestimated.
Fine mapping of transposable element presence/absence variation amongst 216 Arabidopsis strains uncovers widespread novel genetic diversity that underlies differences in transcription and DNA methylation patterns.
Bulk whole genome sequencing data can be used to study the genetic variation present in pathogenic bacterial populations over the time-course of a single infection within a host.
Genome sequencing reveals the evolution and epidemiology of Leishmania donovani in the Indian subcontinent, where epidemics have caused up to 30,000 deaths per year.
Casper K Lumby, Lei Zhao ... Christopher JR Illingworth
Once an influenza infection is established, selection acts efficiently in favouring fitter viral genotypes, its effects being limited only by the short length of a typical infection.