A robust library preparation and variant calling strategy (DigiPico/MutLX) eliminates false positive single nucleotide variants from picogram quantities of DNA following whole genome amplification.

The single-cell eQTLGen consortium aims to pinpoint the cellular contexts in which disease-causing genetic variants affect gene expression and its regulation.

Mutations that allow tumors to evolve and become resistant to treatment can be readily identified with a new sequencing approach.

Strategies to improve public trust in biomedical research are being hindered by a scientific mindset that stifles interest in reform.

An analysis of review, promotion and tenure documents from 129 US and Canadian universities suggests institutions could better fulfill their public missions by changing how they incentivize the public dimensions of faculty work.

A simulation study is used to demonstrate how mistakes in identifying the experimental unit and the unit of analysis can lead to incorrect analyses and inappropriate inferences when reporting research studies.

An analysis of worldwide human genetic variation reveals the footprints of ancient changes in genomic mutation processes.

Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.

Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.

An over-emphasis on novelty is having detrimental effects on science.