1,143 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels

    Anna L Miles et al.
    An unbiased genome-wide human forward genetic screen identifies the vacuolar ATPase complex and assembly factors as regulators of HIF stability through their actions on intracellular iron metabolism.
    1. Cell Biology
    2. Human Biology and Medicine

    Ret function in muscle stem cells points to tyrosine kinase inhibitor therapy for facioscapulohumeral muscular dystrophy

    Louise A Moyle et al.
    Rescue of DUX4-induced muscle pathology by the RET inhibitor Sunitinib reveals the therapeutic potential for treatment of Facioscapulohumeral muscular dystrophy using tyrosine kinase inhibitors.
    1. Genetics and Genomics
    2. Human Biology and Medicine

    Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of facioscapulohumeral muscular dystrophy

    Sujatha Jagannathan et al.
    The myopathic transcription factor DUX4 induces discordant dysregulation of transcript and protein levels, demonstrating a key role for post-transcriptional gene regulation in facioscapulohumeral muscular dystrophy.
    1. Computational and Systems Biology
    2. Developmental Biology

    Temporal modulation of collective cell behavior controls vascular network topology

    Esther Kur et al.
    Tissue-specific temporal regulators impinge on the VEGF/Delta-Notch pathway to vary tip cell selection pace yielding diverse densities of vascular network.
    1. Cell Biology
    2. Human Biology and Medicine

    Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point

    Nicolas Baeyens et al.
    Flow-dependent remodeling of blood vessels is critical for normal physiology and for recovery from arterial blockage in disease; understanding its cellular mechanisms may lead to the development of treatments for patients that are deficient in this process following myocardial infarction or other vascular diseases.
    1. Developmental Biology
    2. Neuroscience

    Radial glia regulate vascular patterning around the developing spinal cord

    Ryota L Matsuoka et al.
    Identification of a novel role for central nervous system-resident progenitors in the patterning of the vascular network around the developing spinal cord.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Dengue vascular leakage is augmented by mast cell degranulation mediated by immunoglobulin Fcγ receptors

    Ayesa Syenina et al.
    Building on previous work (St John et al., 2013), we explain why secondary infection by dengue virus is associated with more severe vascular disease than primary infection.
    1. Neuroscience

    Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy

    Tiffany W Todd et al.
    Nemo-like kinase is a key protein promoting the pathogenesis of spinal and bulbar muscular atrophy.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells

    Mark F Sabbagh et al.
    Genome-wide integration of transcriptome, accessible chromatin, and DNA methylome data from vascular endothelial cells lays the foundation for understanding the gene regulatory circuits that generate organ-specific vascular specialization.
    1. Cell Biology
    2. Neuroscience

    Presynaptic morphology and vesicular composition determine vesicle dynamics in mouse central synapses

    Laurent Guillaud et al.
    In central synapses, the mobility and supply of synaptic vesicles are determined by two independent biological factors: the morphological and structural organization of nerve terminals and the molecular signature of vesicles.

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