1,601 results found
    1. Immunology and Inflammation
    2. Medicine

    Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis

    Temitayo O Idowu et al.
    Matrix metalloprotease (MMP)-14 cleaves Tie2 at three distinct sites within the fibronectin type-III (FN3) domain and its pharmacological blockade inhibits Tie2 pathological shedding to exert barrier protective effects.
    1. Cell Biology
    2. Developmental Biology

    Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling

    Yan Xiong et al.
    Primary cilia on endothelial cells are required for VEGF-A/ VEGFR2-dependent signaling, islet vascularization and, consequently, nutrient delivery and insulin disposal.
    1. Cell Biology
    2. Medicine

    eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin

    Takeshi Ninchoji et al.
    Vascular leakage from pathological vessels in retinopathy aggravates the disease, but endothelial junction stability and barrier integrity can be restored by blocking formation of nitric oxide.
    1. Genetics and Genomics
    2. Neuroscience

    A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture

    Mark F Sabbagh, Jeremy Nathans
    In vitro culture of brain endothelial cells leads to a rapid loss of the blood-brain barrier transcriptional and accessible chromatin landscapes that is resistant to the effects of beta-catenin stabilization.
    1. Medicine

    Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome

    Simone Bersini et al.
    Direct reprogramming of smooth muscle cells from HGPS patients revealed that BMP4 is a key contributor of vascular degeneration and might represent a new therapeutic target.
    1. Developmental Biology

    Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice

    Fabienne Benz et al.
    Endothelial tightening by augmenting low level Wnt/β-catenin activity in vessels of the mouse subfornical organ, influences neuronal activation in water-deprived mice, linking endothelial barrier properties to neuro-vascular coupling.
    1. Cell Biology
    2. Developmental Biology

    YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

    Filipa Neto et al.
    Endothelial YAP/TAZ shape the developing vasculature by orchestrating mechanical inputs with BMP signalling to promote junctional VE-Cadherin turnover and cellular rearrangements.
    1. Computational and Systems Biology
    2. Developmental Biology

    The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium

    Katharina Schlereth et al.
    The acquisition of vascular quiescence during transition to adulthood is driven by distinct transcriptional and epigenetic programs of pro- and anti-angiogenic genes, with the most prominent effect on the suppression of TGFß family signaling.
    1. Neuroscience

    Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose

    Cheng Qian et al.
    Identification of novel vesicular transporters will shed light on to expanding the chemical diversity of neurotransmitters or neuromodulators.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells

    Mark F Sabbagh et al.
    Genome-wide integration of transcriptome, accessible chromatin, and DNA methylome data from vascular endothelial cells lays the foundation for understanding the gene regulatory circuits that generate organ-specific vascular specialization.

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