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Analysis of the mechanism of action of cystic fibrosis corrector drugs reveals signalling pathways potently controlling the proteostasis of the main disease-relevant CFTR mutant.

Parasites with pathogenic variant surface antigens are common in adult malaria patients with a naive immune status.

The common human HAQ,AQ alleles suppress STING1 gain-of-function mutation-induced chronic STING1 inflammation in mice.

Cation chloride cotransporter CCC1 has a central function in plant cells and is the missing ion efflux component of the transport circuit necessary to regulate pH in the lumen of the trans-Golgi-network/early endosome, the major cargo hub in plant cells.

The medial prefrontal cortex and orbitofrontal cortex work in concert to match state representations from feedback to those at choice, and the strength of these common neural codes predict credit assignment precision.

Filopodia driven by class X myosin promote the fusion of mammalian myoblasts in the development of skeletal muscle and are important for the regeneration of skeletal muscle following muscle injury.

GDNF receptor-expressing mesenchymal progenitor subpopulation within skeletal muscle responds to peripheral nerve injury by sensing GDNF and secreting BDNF, thereby directly promoting nerve regeneration through facilitating remyelination by Schwann cells.

Preventing activity of the kinase tumor progression locus 2 modulates microglial activation, reduces T-cell brain infiltration, and is neuroprotective in disease models.

A novel signaling system in heart mitochondria in which the byproduct of energy metabolism, CO₂/bicarbonate, acts as the primary signal to tune mitochondrial ATP production while keeping energy supply in tight synchronization with energy consumption.

The Hox transcription factor Ultrabithorax (Ubx) represses alternative gene programs during lineage development by lineage-specific Polycomb protein complex retention at Ubx-targeted chromatin sites.