Single synaptic vesicle imaging shows that kinetically distinct endocytic pathways are differentially regulated by calcium and temperature, and influence the fidelity of synaptic vesicle protein retrieval.
A discovery of two previously unknown, molecularly distinct fields of cardiac progenitors in zebrafish provides evidence for cardiac laterality prior to the emergence of cardiac septation and allows novel insights into cardiac development and disease.
Proteasomes are protected from autophagic elimination upon carbon starvation by sequestration into cytoplasmic storage granules, which aid cell fitness by providing a cache of proteasomes that can be rapidly remobilized when carbon availability improves.
Plant-unique RAB5 effector 2 (PUF2) is an effector of plant-unique ARA6, which plays a key role in plant endosomal transport, integrating functions of the two plant RAB5 groups by an unprecedented mechanism.
The acquisition of vascular quiescence during transition to adulthood is driven by distinct transcriptional and epigenetic programs of pro- and anti-angiogenic genes, with the most prominent effect on the suppression of TGFß family signaling.
The development of Natural Killer T Cells is controlled by Histone Deacetylase 7, a function that combined with its known role in thymic negative selection provides a potential mechanism explaining its association with tissue-specific autoimmunity in humans.
A specialized conduction pathway for the electrical impulse in the heart, previously thought to be associated with the endothermic mammals and birds only, is also present in the ectothermic crocodiles.
Parallel measurements of pH gradient and membrane potential at the single vesicle level have revealed that the synaptic vesicle acidification is initiated by removal of its clathrin coat, which blocks vesicular ATPase activity.