Mayalen Etcheverry, Clément Moulin-Frier ... Michael Levin
A novel methodology, using diversity search AI algorithms, for exploring the space of possible behaviors of gene regulatory networks, from the perspective of generic problem-solving agents navigating their environment.
Johann Mignolet, Guillaume Cerckel ... Pascal Hols
A new cell–cell communication system in Streptococcus salivarius, a human gut commensal, discriminates between close signaling molecules to specifically produce bacteriocin-based antimicrobials and disconnects it from foreign DNA acquisition.
Mathieu Cayla, Lindsay McDonald ... Keith Matthews
A trypanosome DYRK kinase that exhibits fundamental differences to conventional DYRK family regulation links parasite quorum sensing, signal transduction and developmental gene expression.
David W Hawman, Kimberly Meade-White ... Heinz Feldmann
A mouse-adapted strain of Crimean-Congo hemorrhagic fever virus that recapitulates human disease in wild-type mice significantly improves our ability to study Crimean-Congo hemorrhagic fever virus pathogenesis.
Nicolas Carraro, Xavier Richard ... Jan Roelof van der Meer
A new multistep hierarchical cascade controls activation of an integrative and conjugative element in a small subpopulation of cells in its bacterial host, yielding proficient DNA transferring cells.
Host restriction factors that block cross-species transmission also play a role in limiting the replication of highly-adapted HIV-1 in IFN-stimulated cells.
The reclassification of gene editing as "GM" will impact on European plant sciences, making it more difficult to validate new traits in field trials and drive forward innovation.
With standardized insecticide-resistance assays failing to inform mosquito-control efficacy due to genotype-by-environment effects, practical resistance monitoring under relevant local conditions is needed to correlate resistance, mosquito-control efficacy, and disease epidemiology.
Strong reduction in malaria transmission by genetically modified mosquitoes is achieved in the laboratory using a dual gene drive that simultaneously propagates an antiparasitic factor and a parasite-detrimental mosquito mutation.
