155 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Scrutinized lipid utilization disrupts Amphotericin-B responsiveness in clinical isolates of Leishmania donovani

    Supratim Pradhan, Dhruba Dhar ... Budhaditya Mukherjee
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

    Erin M Ritchie, Dilan Acar ... Yishi Jin
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cancer Biology

    Deuterium Metabolic Imaging Phenotypes Mouse Glioblastoma Heterogeneity Through Glucose Turnover Kinetics

    Rui V Simões, Rafael N Henriques ... Noam Shemesh
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Neuroscience
    2. Physics of Living Systems

    A Deep Learning Pipeline for Mapping in situ Network-level Neurovascular Coupling in Multi-photon Fluorescence Microscopy

    Matthew Rozak, James Mester ... Bojana Stefanovic
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Incomplete
    1. Developmental Biology
    2. Genetics and Genomics

    Determining the effects of paternal obesity on sperm chromatin at histone H3 lysine 4 tri-methylation in relation to the placental transcriptome and cellular composition

    Anne-Sophie Pepin, Patrycja A Jazwiec ... Sarah Kimmins
    Epigenomic and transcriptomic analysis reveals that paternal obesity influences sperm histone H3 lysine 4 tri-methylation enrichment and placenta gene expression, which in turn negatively impact its development and function in a manner that may contribute to metabolic disease in offspring.
    1. Computational and Systems Biology
    2. Developmental Biology

    Dynamic readout of the Hh gradient in the Drosophila wing disc reveals pattern-specific tradeoffs between robustness and precision

    Rosalío Reyes, Arthur D Lander, Marcos Nahmad
    Theoretical and experimental evidence that Hh signaling dynamics balances robust positioning and sharpness of different target genes in the Drosophila wing disc.
    1. Genetics and Genomics

    Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings

    Shek Man Chim, Kristen Howell ... Regeneron Genetics Center
    Loss of the Zinc transporter SLC39A5 protects from obesity-driven hyperglycemia and liver pathology.
    1. Neuroscience

    Circuit function is more robust to changes in synaptic than intrinsic conductances

    Zachary Fournier, Leandro M Alonso, Eve Marder
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation

    CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells

    Xiaoyu Meng, Yezhang Zhu ... Lie Wang
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid

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