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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Differential expression of Lutheran/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration

    Yasushi Miura, Satoshi Matsui ... Minoru Tanaka
    Lutheran is a novel marker for classification of bile duct remodeling in distinct liver injury, and an interesting functional molecule for investigating the nature of liver stem/progenitor cells during regeneration.
    1. Developmental Biology

    Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling

    Michelle I Lin, Emily N Price ... Leonard I Zon
    Angiopoietin-like proteins signal through notch via receptor interaction and can regulate Notch cleavage/activation.
    1. Developmental Biology

    Spatial patterning of liver progenitor cell differentiation mediated by cellular contractility and Notch signaling

    Kerim B Kaylan, Ian C Berg ... Gregory H Underhill
    Mechanical stress plays a cooperative role with Notch in biliary differentiation of liver progenitors, supporting a model of liver development in which biomechanical cues are key inducers of cell fate.
    1. Developmental Biology

    Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence

    Pankaj Sahai-Hernandez, Claire Pouget ... David Traver
    A rare population of endothelial cells emerges from a bipotent muscle progenitor population in the paraxial mesoderm and provides niche support to induce hematopoietic stem cells.
    1. Plant Biology

    Increased signal-to-noise ratios within experimental field trials by regressing spatially distributed soil properties as principal components

    Jeffrey C Berry, Mingsheng Qi ... Rebecca S Bart
    A method to reduce the noise present in field experiments by accounting for heterogeneity in field soils.
    1. Computational and Systems Biology
    2. Neuroscience

    Probable nature of higher-dimensional symmetries underlying mammalian grid-cell activity patterns

    Alexander Mathis, Martin B Stemmler, Andreas VM Herz
    Mathematical analysis confirms that hexagonal patterns of neuronal activity are the most efficient means for the brain to represent 2D space, and predicts that activity patterns resembling densely packed lattices are optimal for representing 3D space.
    1. Cell Biology
    2. Developmental Biology

    Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos

    Amanda D Yzaguirre, Arun Padmanabhan ... Jonathan A Epstein
    Ras-GAP activity suppresses the hemogenic potential of the embryonic heart.
    1. Genetics and Genomics
    2. Neuroscience

    Machine learning sequence prioritization for cell type-specific enhancer design

    Alyssa J Lawler, Easwaran Ramamurthy ... Andreas R Pfenning
    A new cross-species machine learning-based strategy is applied to find enhancers that specifically label parvalbumin neurons in the mouse and macaque.
    1. Evolutionary Biology

    mirror determines the far posterior domain in butterfly wings

    Martik Chatterjee, Xin Y. Yu ... Robert D. Reed
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Flatworm-specific transcriptional regulators promote the specification of tegumental progenitors in Schistosoma mansoni

    George R Wendt, Julie NR Collins ... James J Collins III
    The specification of tegumental progenitor cells in Schistosoma mansoni relies on a pair of flatworm-specific transcription factors that are related to genes regulating epidermal specification in free-living flatworms.