1,068 results found
    1. Neuroscience

    Modulation of tonotopic ventral medial geniculate body is behaviorally relevant for speech recognition

    Paul Glad Mihai et al.
    Ultra-high field neuroimaging dissects the ventral medial geniculate body (vMGB) of the primary auditory pathway from other MGB subregions and reveals that vMGB top-down modulation is relevant for speech recognition.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11

    Iga Kucharska et al.
    A comprehensive structural analysis of inhibitory murine antibody 3D11 binding to Plasmodium berghei circumsporozoite protein reveals common mechanisms of antibody evolution in mammals against Plasmodium parasites.
    1. Neuroscience

    An essential role of acetylcholine-glutamate synergy at habenular synapses in nicotine dependence

    Silke Frahm et al.
    Local elimination of acetylcholine synthesis in habenular neurons demonstrates a key role for vesicular synergy and neurotransmitter co-release in nicotine dependence.
    1. Neuroscience

    Direct neural pathways convey distinct visual information to Drosophila mushroom bodies

    Katrin Vogt et al.
    Building on previous work (Vogt et al. 2014), separate visual pathways have been identified to convey information for brightness and color to the learning-related area of the Drosophila brain.
    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon et al.
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
    1. Developmental Biology
    2. Evolutionary Biology

    An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1

    David S Lorberbaum et al.
    The seemingly simple, constitutive response of the patched/Ptch1 gene to Hedgehog signaling is in fact regulated by large batteries of context-specific Hedgehog-responsive enhancers in both fly and mouse, allowing tissue-specific tuning of the Hedgehog pathway in animal development and evolution.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models

    M Catarina Silva et al.
    A new Cereblon-recruiting bifunctional tau ligand, QC-01-175, promotes aberrant tau degradation and rescue of stress vulnerability in human neuronal cell models of tauopathy.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Guanidine hydrochloride reactivates an ancient septin hetero-oligomer assembly pathway in budding yeast

    Courtney R Johnson et al.
    A naturally-occurring small molecule acts as a chemical chaperone in vivo to alter the folding of a budding yeast septin and promote an oligomerization pathway that was lost during evolution.
    1. Structural Biology and Molecular Biophysics

    Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain

    Zhicheng Zuo et al.
    The catalytic activation of the Cas9 HNH domain involves a unique conformational change in the ββα-metal motif that is collectively driven by the interactions with the metal ions and DNA.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Compaction and segregation of sister chromatids via active loop extrusion

    Anton Goloborodko et al.
    Loop extrusion can robustly compact, segregate and disentangle mammalian chromosomes, suggesting it is a universal mechanism of genome folding during cell division.

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