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    1. Developmental Biology
    2. Neuroscience

    Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development

    Denise M Poltavski, Alexander T Cunha ... Takako Makita
    Neural crest and placode lineages both contribute to the enteric nervous system, divergently utilizing Edn3-Ednrb and GDNF-Ret signaling.
    1. Neuroscience

    Cortical adaptation to sound reverberation

    Aleksandar Z Ivanov, Andrew J King ... Nicol S Harper
    The auditory system adapts to the changing acoustics of reverberant environments by temporally shifting the inhibitory tuning of cortical neurons to reduce the effects of reverberation.
    1. Neuroscience

    Learning of state representation in recurrent network: the power of random feedback and biological constraints

    Takayuki Tsurumi, Ayaka Kato ... Kenji Morita
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

    François Kroll, Joshua Donnelly ... Jason Rihel
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience

    Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues

    Adam Glaser, Jayaram Chandrashekar ... Karel Svoboda
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience

    Altered gating of Kv1.4 in the nucleus accumbens suppresses motivation for reward

    Bernadette O'Donovan, Adewale Adeluyi ... Pavel I Ortinski
    Low effort-based motivation to pursue naturally rewarding stimuli can be increased pharmacologically, by targeting inactivation of a single voltage-gated potassium channel within the mesolimbic dopamine reward system.
    1. Developmental Biology
    2. Evolutionary Biology

    Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network

    Joaquín Letelier, Lorena Buono ... Juan R Martínez-Morales
    Depletion of vsx genes in zebrafish confirms a conserved role in bipolar cells specification across vertebrates, but do not interfere with the formation of the neural retina domain, which reveal an unexpected robustness of the genetic network sustaining the retina.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Human axial progenitors generate trunk neural crest cells in vitro

    Thomas JR Frith, Ilaria Granata ... Anestis Tsakiridis
    Pluripotent stem cell differentiation provides insight into how neural crest subtypes of distinct axial identity are patterned in human embryos.
    1. Neuroscience

    Inhibition in the auditory brainstem enhances signal representation and regulates gain in complex acoustic environments

    Christian Keine, Rudolf Rübsamen, Bernhard Englitz
    Inhibition in the brainstem has further roles beyond temporal sharpening and improves reproduction for a multitude of sounds.
    1. Computational and Systems Biology
    2. Neuroscience

    On the objectivity, reliability, and validity of deep learning enabled bioimage analyses

    Dennis Segebarth, Matthias Griebel ... Robert Blum
    A comparison of different bioimage analysis pipelines reveals how deep learning can be used for automatized and reliable analysis of fluorescent features in biological datasets.