604 results found
    1. Neuroscience

    Non-thalamic origin of zebrafish sensory nuclei implies convergent evolution of visual pathways in amniotes and teleosts

    Solal Bloch et al.
    Mesencephalic origin of the zebrafish thalamocortical-like visual projection neurons indicates independent evolution of tectofugal visual pathways in amniotes and teleosts.
    1. Computational and Systems Biology

    Neural arbitration between social and individual learning systems

    Andreea Oliviana Diaconescu et al.
    Arbitration is formalised as the relative precision of predictions afforded by reward and social learning systems and is represented in modality-specific dopaminergic and dopaminoceptive regions, including the midbrain and amygdala.
    1. Neuroscience

    The effects of chloride dynamics on substantia nigra pars reticulata responses to pallidal and striatal inputs

    Ryan S Phillips et al.
    The effects of chloride homeostasis can explain diverse responses of basal ganglia output neurons to putatively inhibitory inputs and may tune these neurons' synchrony, oscillations and behavior in decision-making scenarios.
    1. Medicine
    2. Neuroscience

    What is the true discharge rate and pattern of the striatal projection neurons in Parkinson’s disease and Dystonia?

    Dan Valsky et al.
    Aberrant striatal signaling does not induce drastic changes in the spontaneous discharge rate and pattern of the striatal projection neurons in Parkinson’s disease and Dystonia.
    1. Ecology
    2. Evolutionary Biology

    Lichen mimesis in mid-Mesozoic lacewings

    Hui Fang et al.
    The earliest fossil evidence of a mimetic relationship between the Jurassic moth lacewing Lichenipolystoechotes and its co-occurring fossil lichen Daohugouthallus predates modern lichen-insect associations by 165 million years.
    1. Neuroscience

    Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release

    Paul F Kramer et al.
    GABA-A receptors on dopamine neuron axons not only depolarize the membrane but also limit action potential propagation, an effect potentiated by positive allosteric modulators of GABA-A receptors like diazepam (Valium).
    1. Neuroscience

    Amphetamine reduces reward encoding and stabilizes neural dynamics in rat anterior cingulate cortex

    Saeedeh Hashemnia et al.
    Amphetamine reduces reward signaling by neurons in rat prefrontal cortex, but increases the stability of population dynamics, which account for animals’ increased task engagement, despite reduced reward motivation.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation

    CM Schooling et al.
    Identifying why statins differ from other major lipid modifiers has revealed a new modifiable target of intervention for cardiovascular disease relevant to both drug development and optimal statin use.
    1. Neuroscience

    Learning prediction error neurons in a canonical interneuron circuit

    Loreen Hertäg, Henning Sprekeler
    The formation and refinement of prediction error circuits relies on an experience-dependent balance of excitation and inhibition in canonical microcircuits.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Activation of a neural stem cell transcriptional program in parenchymal astrocytes

    Jens P Magnusson et al.
    Parenchymal astrocytes are quiescent neural stem cells whose neurogenic potential can be unleashed by targeted manipulations guided by single-cell RNA sequencing data.

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