467 results found
    1. Neuroscience

    C. elegans orthologs MUT-7/CeWRN-1 of Werner syndrome protein regulate neuronal plasticity

    Tsung-Yuan Hsu et al.
    The olfactory learning of Caenorhabditis elegans shows that the exonuclease and helicase domains of human Werner syndrome protein (WRN) coordinately regulate the biogenesis of small interfering RNAs to promote neuronal plasticity.
    1. Developmental Biology

    Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness

    Jordi Cayuso et al.
    Boundary cell identity and sharpening of borders are coupled in hindbrain development since both are regulated by mechanical tension.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Hemozoin produced by mammals confers heme tolerance

    Rini H Pek et al.
    Heme accumulation is toxic, but deficiency of the heme transporter HRG1/SLC48A1 causes heme sequestration and crystallization into hemozoin within enlarged lysosomes of macrophages, thereby conferring heme tolerance to mammals.
    1. Neuroscience

    Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts

    Mathan K Raja et al.
    Synaptophysins and gyrins dampen synaptic strength selectively at low frequencies, hinting that synaptic transmission may play a frequency filtering role in biological computation that is more general than currently envisioned.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A single-parasite transcriptional atlas of Toxoplasma Gondii reveals novel control of antigen expression

    Yuan Xue et al.
    Single-cell RNA-sequencing resolves the transcriptional landscape of asexual development in Toxoplasma gondii, revealing concerted genetic programs to Plasmodiumfalciparum and a novel transcriptional factor that controls antigen switching.
    1. Developmental Biology

    Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis

    Takashi Koyama et al.
    In Drosophila melanogaster, nutrition controls body size by acting through the Forkhead Box class O (FoxO)/Ultraspiracle complex to regulate nutrition-sensitive ecdysone biosynthesis, thereby controlling the switch to stop growth.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Protein-mediated RNA folding governs sequence-specific interactions between rotavirus genome segments

    Alexander Borodavka et al.
    In rotaviruses, the selective packaging of eleven distinct genomic RNA segments requires virus-encoded protein NSP2 to alter the RNA structures, facilitating their interactions with each other.
    1. Structural Biology and Molecular Biophysics

    Structural basis of mitochondrial translation

    Shintaro Aibara et al.
    Structural analysis of translating human mitoribosome illustrates elemental steps of translation in mitochondria.
    1. Developmental Biology
    2. Genetics and Genomics

    Cardiac pathologies in mouse loss of imprinting models are due to misexpression of H19 long noncoding RNA

    Ki-Sun Park et al.
    Maternal loss of imprinting at the Igf2/H19 locus reduces expression of H19 lncRNA and thereby leads to progressive cardiac pathologies in a mouse Beckwith–Wiedemann syndrome model.
    1. Cancer Biology
    2. Developmental Biology

    PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis

    Genevieve C Kendall et al.
    The basic helix-loop-helix transcription factor, HES3, acts downstream of the PAX3-FOXO1 fusion oncogene to impair muscle differentiation and promote tumorigenesis in rhabdomyosarcoma, a childhood muscle cancer.

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