268 results found
    1. Neuroscience

    GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice

    Srikanta Chowdhury et al.
    Functional identification of GABAergic neurons in the ventral tegmental area as a important neuronal subpopulation regulating non-rapid eye movement (NREM) sleep in mice.
    1. Neuroscience

    HCN2 channels in the ventral tegmental area regulate behavioral responses to chronic stress

    Peng Zhong et al.
    HCN2 channels in the ventral tegmental area play an important role in the pathophysiology of chronic mild stress-induced behavioral deficits.
    1. Neuroscience

    Synaptic Plasticity: Hijacking translation in addiction

    Alicia Izquierdo, Alcino J Silva
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    1. Neuroscience

    Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress

    Abigail M Polter et al.
    Rats exposed to a single stressful event experience days-long constitutive activation of the kappa opioid receptor at inhibitory synapses in part of the brain’s reward system, which increases their drug-seeking behavior.
    1. Neuroscience

    Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation

    Ming Chen et al.
    Experiments examining the actions of morphine on single neurons from one of the brain's reward centers, the VTA, reveal the mechanism by which the drug exerts its hedonic effects.
    1. Neuroscience

    Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine

    Wei Huang et al.
    Vulnerability to cocaine addiction during adolescence depends on translational control.
    1. Neuroscience

    Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward

    Zhijian Zhang et al.
    The VTA-mOT DAergic pathway mediates a variety of naturalistic reward processes and different types of preferences including odor-preference.
    1. Neuroscience

    Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α

    Andon N Placzek et al.
    An evolutionarily conserved mechanism involving translational control by p-eIF2α underlies vulnerability to nicotine addiction.
    1. Neuroscience

    Impairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid-triggered reward deficits

    Bárbara Coimbra et al.
    LDT-VTA dysfunction induced by prenatal glucocorticoid exposure leads to reward deficits that can be ameliorated by selective optogenetic activation of this circuit.
    1. Neuroscience

    Oxytocin functions as a spatiotemporal filter for excitatory synaptic inputs to VTA dopamine neurons

    Lei Xiao et al.
    Oxytocin, a peptide linked to the processing of socially meaningful stimuli, modulates excitatory synaptic transmission in dopaminergic neurons of ventral tegmental area via retrograde endocannabinoid signaling, acting as a pathway-specific temporal filter for synaptic inputs.

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