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A single amino acid change in a neuronal ion channel called KCNQ2 blocks ion flow, prevents protein localization on axons, and results in severe epilepsy and slowed neurological development.

Structural network topology develops during adolescence to facilitate activation of the fronto-parietal executive system with lower theoretical energetic cost.

Genetic manipulations reveal how the spatiotemporal expression pattern of two RNA-binding proteins regulates the eventual number of motoneurons in a Drosophila neuronal lineage.

Cd59 and developmental inflammation are key players in myelinating glial cell development, highlighting the collaboration between glia and the innate immune system to ensure normal neural development.

Stride-related modulated firing by neurons of the cerebellar nuclei is required for smooth execution of practiced locomotion and persists more easily with synchronous than asynchronous Purkinje-mediated inhibition.

An easy-to-implement antibody validation pipeline addresses the reproducibility crisis resulting from the use of non-specific antibodies.

Animal-to-animal variability in neuronal geometry may be compensated for by compact electrotonic structure.

Invasive electrophysiological recording measures neuronal transmembrane current timescales across human cortex, which lengthens from sensory to association regions, follows variations in ion channel expressions, and alters with behavior and aging.

Genetic variation in a biogenic amines receptor underlies a means of gain control for nonassociative learning and hence an important form of attention that is the basis for tradeoffs in foraging in a social collective.

fMRI evidence for off-task replay predicts subsequent replanning behavior in humans, suggesting that learning from simulated experience during replay helps update past policies in reinforcement learning.