TcMAC21 is an appropriate “next gen” mouse model for DS research, and provides a proof of concept of using artificial chromosomes to generate non-mosaic humanized animal models of chromosome disorders.
Polyunsaturated fatty acid analogues show selectivity for different cardiac ion channels, suggesting their potential use for the treatment of different subtypes of Long QT Syndrome.
AKAP6 is a site-specific adaptor required and sufficient to anchor centrosomal proteins and golgi to the nuclear envelope and establishes a non-centrosomal microtubule organization center (ncMTOC).
Hypoplastic left heart syndrome is reflected by reduced proliferative capacity of patient iPSC-derived cardiomyocytes and requires the activity of LRP2/APOB proteins, likely in conjunction with SHH and WNT signaling pathways.
Macrophage production of MT1-MMP upon MI contributes to adverse cardiac remodeling and worsened function by promoting EndMT via TGFB, suggesting MT1-MMP inhibition as a therapeutic option for patients with MI.
Repositioning the type II ryanodine receptors on the sarcoplasmic reticulum membrane is a potential new mechanism regulating their function, and therefore the strength of cardiac contraction.
A method for measuring p300 chromatin occupancy in specific lineages of mouse tissues was used to map endothelial enhancers and to identify previously unrecognized angiogenesis-related sequence motifs.
Second-order guidance, a novel mechanism by which an initial guidance cue controls expression of a second guidance receptor, is required for precise refinement of axon trajectories during PNS development.
Mass spectroscopy, molecular modeling and/or molecular dynamics simulations reveal how acetylation regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation.
