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    1. Medicine
    2. Neuroscience

    Autism: Balancing excitation and inhibition in the autistic brain

    Charlotte M Pretzsch, Dorothea L Floris
    A metric called the Hurst exponent could be a useful biomarker for studies exploring brain differences between men and women with autism spectrum disorder.
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    1. Neuroscience

    M2 cortex-dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington’s disease

    Sara Fernández-García et al.
    M2 cortex-dorsolateral striatum circuit is functionally altered in Huntington's disease and, by boosting its activity, we reverse symptoms at behavioral, physiological, and morphological level in symptomatic mice.
    1. Neuroscience

    Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats

    Robert AR Drake et al.
    Alterations to brain network communication leading to a progressive loss in descending inhibitory modulation of the spinal cord is a key determinate of pain state development following peripheral nerve injury.
    1. Neuroscience

    Preparation for upcoming attentional states in the hippocampus and medial prefrontal cortex

    Eren Günseli, Mariam Aly
    Memory guides attention by enabling preparation for upcoming states in the hippocampus and medial prefrontal cortex.
    1. Neuroscience

    Molecular and anatomical organization of the dorsal raphe nucleus

    Kee Wui Huang et al.
    The dorsal raphe nucleus contains transcriptionally diverse cell classes that include subtypes of serotonergic neurons with distinct molecular and anatomical signatures.
    1. Neuroscience

    The hippocampus supports deliberation during value-based decisions

    Akram Bakkour et al.
    The deliberation involved in simple preference decisions, such as those between two familiar snacks, depends on the hippocampus.
    1. Neuroscience

    Motor thalamus supports striatum-driven reinforcement

    Arnaud L Lalive et al.
    While the basal ganglia have long been thought to mediate learning through dopamine-dependent striatal plasticity, their regulation of motor thalamus plays an unexpected and critical role in reinforcement.
    1. Neuroscience

    A connectional hub in the rostral anterior cingulate cortex links areas of emotion and cognitive control

    Wei Tang et al.
    A hub in the rostral anterior cingulate cortex receives unusually high and functionally diverse inputs, providing a biological interface between motivation, incentive based learning, and decision making.
    1. Neuroscience

    Distinct neural contributions to metacognition for detecting, but not discriminating visual stimuli

    Matan Mazor et al.
    Combining psychophysics and functional MRI reveals a qualitative asymmetry in neural engagement when reflecting on whether a stimulus is seen (detection) compared to reflecting on what a stimulus is (discrimination).
    1. Neuroscience

    Model-based fMRI reveals dissimilarity processes underlying base rate neglect

    Sean R O'Bryan et al.
    Model-based imaging shows that the rostrolateral prefrontal cortex supports dissimilarity-based heuristics that people may use when they are confronted with ambiguous scenarios.