3,288 results found
    1. Biochemistry and Chemical Biology

    Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection

    Donghyuk Shin et al.
    A novel class of bacterial OTU deubiquitinases provides insights on the distinct roles of bacterial deubiquitinases in host–pathogen interactions.
    1. Neuroscience

    The actin-modulating protein synaptopodin mediates long-term survival of dendritic spines

    Kenrick Yap et al.
    Long-term imaging of dentate granule cells reveals that the presence of synaptopodin within large spines, rather than their size, conveys long-term stability to large spines.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Arrayed CRISPRi and quantitative imaging describe the morphotypic landscape of essential mycobacterial genes

    Timothy J de Wet et al.
    A high-throughput functional genomics approach combining inducible CRISPR-interference and quantitative imaging yields an atlas of 'phenoprints' to guide gene function assignments, identify metabolic pathway-specific morphotypes, and inform antibiotic mechanism-of-action studies.
    1. Ecology
    2. Neuroscience

    BiteOscope, an open platform to study mosquito biting behavior

    Felix JH Hol et al.
    A new tool to visualize blood-feeding mosquitoes in high resolution and quantitatively characterize their behavior sheds light on contact-dependent sensing and blood-feeding dynamics of several medically relevant mosquito species.
    1. Developmental Biology

    m6A RNA methylation impacts fate choices during skin morphogenesis

    Linghe Xi et al.
    METTL3-mediated m6A modification maintains proper cell lineage specification during skin epithelium morphogenesis by coupling transcription and translation of key regulatory pathways.
    1. Developmental Biology
    2. Neuroscience

    Glial insulin regulates cooperative or antagonistic Golden goal/Flamingo interactions during photoreceptor axon guidance

    Hiroki Takechi et al.
    Timely regulation of growth cone dynamics, including filopodial and cytoskeletal rearrangements through phosphorylation signals from glial cells, shapes the photoreceptor axon targeting.
    1. Cell Biology
    2. Neuroscience

    Antagonistic roles for Ataxin-2 structured and disordered domains in RNP condensation

    Amanjot Singh et al.
    Ataxin-2 interacts with neuronal mRNA in RNP granules.
    1. Biochemistry and Chemical Biology

    Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

    Rajendra Uprety et al.
    The structure-based design established a new approach to control pathway-selective activation of opioid receptors, resulting in new dual MOR/KOR G-protein biased agonist analgesics with attenuated liabilities.
    1. Neuroscience

    A machine-vision approach for automated pain measurement at millisecond timescales

    Jessica M Jones et al.
    Development of a fully automated pain scale using machine learning tools in computational neuroethology and creation of new software, reveals a robust circuit-dissection compatible platform for objective pain measurement.
    1. Developmental Biology

    Geometric models for robust encoding of dynamical information into embryonic patterns

    Laurent Jutras-Dubé et al.
    Propagation, speed and shapes of genetic waves of expression during development can be modeled by a simple interplay between two transcriptional modules (dynamic/static), which explains robustness and precision of patterning.

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