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A novel role of motoneuron Wnts in regulating presynaptic development at the neuromuscular junction.

SNX6 regulates the distribution of a protein called Homer1b/c to distal dendrites, enabling the latter to stabilize the synapses and thereby support memory formation.

The transcriptional cofactor HPK-1 (homeodomain-interacting protein kinase) functions as a key regulator of multiple proteostatic stress responses, each originating from discrete neuronal subtypes within the Caenorhabditis elegans nervous system to preserve neuronal health and maintain organismal proteostasis during normal aging.

Glycolysis is locally enhanced and redirected in zebrafish to generate lactate, which functions as a signaling molecule to fully activate Fgf target genes required for proper sensory and neural development.

There are at least two separate pathways for AMPA receptor recycling, which are regulated by synaptic activity.

Rab26 selectively directs synaptic and secretory vesicles into preautophagosomal structures, suggesting the presence of a novel pathway (vesiculophagy) for degradation of synaptic vesicles.

The control of SEC23B degradation by SCF^FBXW5 and ULK1 regulates the autophagy.

Using a suite of CRISPR technologies, unique chemical tools, and carefully designed biochemical and cell biological assays, we define the mechanism of action of Retro-2, an inhibitor of retrograde toxins.

SNARE protein tomosyn differentially affects two main secretory pathways in mammalian neurons.

Genomic associations with lifespan principally reflect heart disease/smoking/dementia but not other cancers, and distinguish lifespan differences of five years between top/bottom deciles of a score derived from DNA alone.