Joana R Carvalho, Isabela C Fortunato ... Claudio A Franco
Analysis of axial polarity distributions shows that Wnt5a regulates collective cell migration in vivo by stabilizing vinculin at adherens junctions and fine-tuning mechanocoupling between neighbouring cells.
High-resolution multiphoton microscopy reveals coupling of blood vessel subtype with expanding osteoblasts at the bone regeneration interface, further highlighting the heterogeneity of oxygen microenvironment and its impact on cellular energy metabolism of bone and vessel forming cells.
Correlated magnetic resonance imaging and ultramicroscopy resolves macro- and microvasculature in glioma models and allows treatment monitoring of antiangiogenic therapy.
Increasing levels of the growth factor Vegfa disrupt blood vessel branching morphogenesis and drive diameter increase by synchronizing Notch signalling fluctuations between endothelial cells.
Improved 3D and 4D imaging of neurovascular processes across scales reveals new insights into eye disease mouse models and shows retinal vessels are significantly distorted using standard flat-mount confocal imaging.
Francesco Andreata, Marc Clément ... Giuseppina Caligiuri
CD31 plays a pivotal role in neutrophil migration to inflamed sites by localizing to the uropod and promoting effective actin/integrin polarization and detachment, shedding light on the molecular mechanisms underlying extravasation and inflammation response.
Three-dimensional imaging was used to identify structural and quantitative features of developing lymphatics in the kidneys of mice, humans and in a genetic mouse model of polycystic kidney disease.
Valentina Barrera, Ian James Callum MacCormick ... Simon Peter Harding
Clinical, clinicopathological and image data from Malawian children shows that sequestration in P. falciparum cerebral malaria is visible clinically in the eye as orange retinal vessels and is strongly associated with death.
