1,013 results found
    1. Neuroscience

    Regenerating hair cells in vestibular sensory epithelia from humans

    Ruth Rebecca Taylor et al.
    Immunolabelling and morphological assessment, complemented by complete transcriptomic analysis, demonstrates that supporting cells can be induced to convert towards a hair cell-like phenotype in human vestibular sensory epithelia.
    1. Neuroscience

    Neuronal variability and tuning are balanced to optimize naturalistic self-motion coding in primate vestibular pathways

    Diana E Mitchell et al.
    A match between neuronal variability and tuning enables optimized coding of natural self-motion in early vestibular pathways.
    1. Neuroscience

    Robust vestibular self-motion signals in macaque posterior cingulate region

    Bingyu Liu et al.
    Macaque posterior cingulate region carries vestibular dominant self-motion signals with plentiful temporal components that could be useful for process of path integration.
    1. Neuroscience

    Down regulation of vestibular balance stabilizing mechanisms to enable transition between motor states

    Romain Tisserand et al.
    Down regulation of the gain from the vestibular sensory sources prior to the initiation of movement is a motor control solution to overcome the reflex-stabilizing mechanisms to enable motion from a postural orientation.
    1. Neuroscience

    A primal role for the vestibular sense in the development of coordinated locomotion

    David E Ehrlich, David Schoppik
    Zebrafish use their sense of gravity and their cerebellum to coordinate the fin and body movements that, as they develop, allow them to better maintain balance as they climb.
    1. Neuroscience

    Spatiotemporal dynamics of multi-vesicular release is determined by heterogeneity of release sites within central synapses

    Dario Maschi, Vitaly A Klyachko
    Release site heterogeneity represents a previously unknown level of structural and functional organization within individual active zones in central synapses, which determines the spatiotemporal dynamics of multi-vesicular release.
    1. Neuroscience

    Distinct spatial coordinate of visual and vestibular heading signals in macaque FEFsem and MSTd

    Lihua Yang, Yong Gu
    In both frontal and temporal–parietal visual cortices of macaque, distinct spatial coordinates of visual and vestibular signals are predominantly eye centered and head centered, respectively.
    1. Neuroscience

    A unified internal model theory to resolve the paradox of active versus passive self-motion sensation

    Jean Laurens, Dora E Angelaki
    Central vestibular regions in the brainstem and cerebellum perform dynamic Bayesian inference to combine motor commands and sensory signals into an optimal estimate of self-motion.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site

    Marijke Brams et al.
    Development of nanobodies against a model pentameric ligand-gated ion channel demonstrates they can be functionally active as negative or positive allosteric modulators and offers opportunities for future drug development.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells

    Heidi Hehnly et al.
    A protein kinase complex that is important for cell division is lost in testicular seminoma, which is a common cancer in men.

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