An accurate, robust, and lightweight technique for measuring eye movements in mice was developed using magnetic sensing, yielding the first high resolution recordings of eye movements in freely moving mice.
Purkinje cells of the cerebellum, a conserved vertebrate brain region important for sensorimotor integration, receive sensory and motor information from distinct input streams and are functionally clustered into modules reflecting the larval zebrafish's behavioral repertoire.
Computational modeling and molecular-biological analysis reveal the role of mechanical force and downstream Yap signaling in growth control during the development and regeneration of sensory epithelium of the inner ear.
Motor training decreased the unit synaptic response and suppressed induction of long-term depression at parallel fiber to Purkinje cell synapses in the cerebellum, supporting involvement of long-term depression in motor learning.
Patterned optogenetic stimulation and analysis of neural activity provide convergent evidence that cerebellar Purkinje cells drive eye movements with a rapid rate code, without an additional contribution of spike irregularity.
Physiological and behavioral analyses show that expression of cerebellar whisker learning can be mediated by increased simple spike activity, depending on LTP induction at parallel fiber to Purkinje cell synapses.