4,737 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Neuroimaging and behavioral evidence that violent video games exert no negative effect on human empathy for pain and emotional reactivity to violence

    Lukas Leopold Lengersdorff, Isabella C Wagner ... Claus Lamm
    After playing violent video games for 7 hr over the course of 2 weeks, human male participants show neither signs of decreased empathy for the pain of another person nor of decreased responsivity to violent images.
    1. Neuroscience

    Rapid reconstruction of neural circuits using tissue expansion and light sheet microscopy

    Joshua L Lillvis, Hideo Otsuna ... Barry J Dickson
    A new approach for fast, sparse neural circuit mapping allows circuit structure, physiology, and behavior to be quantified in the same animal and across many animals.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation

    Edmundo G Vides, Ayan Adhikari ... Suzanne R Pfeffer
    Parkinson’s disease-associated LRRK2 kinase is recruited to membranes by its Rab GTPase substrates, and LRRK2 is both retained on membranes and further activated there by cooperative interaction with the phosphorylated Rab proteins that it generates.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Linking functional and molecular mechanisms of host resilience to malaria infection

    Tsukushi Kamiya, Nicole M Davis ... Nicole Mideo
    With a data-driven mathematical modelling approach, within-host ecological information alone can provide clues on the mechanistic basis of diverse malaria infection outcomes.
    1. Neuroscience

    anTraX, a software package for high-throughput video tracking of color-tagged insects

    Asaf Gal, Jonathan Saragosti, Daniel JC Kronauer
    anTraX is an algorithm and software package that facilitates automated analyses of insect social behavior in species and experimental settings that are not accessible with currently existing technology.
    1. Neuroscience
    2. Physics of Living Systems

    Gigapixel imaging with a novel multi-camera array microscope

    Eric E Thomson, Mark Harfouche ... Eva A Naumann
    A new multi camera imaging platform simultaneously captures large-area, high-resolution video of unconstrained small model organisms and provides behavioral measurements that span multiple spatial scales.
    1. Neuroscience

    DeepEthogram, a machine learning pipeline for supervised behavior classification from raw pixels

    James P Bohnslav, Nivanthika K Wimalasena ... Christopher D Harvey
    DeepEthogram automatically classifies animal behavior videos into researcher-defined behaviors of interest, saving researcher time and enabling more detailed downstream analysis of behavior.
    1. Neuroscience

    Behavioral evidence for memory replay of video episodes in the macaque

    Shuzhen Zuo, Lei Wang ... Sze Chai Kwok
    Macaque monkeys temporally compress past experiences and use a forward-replay mechanism during judgment of temporal-order between episodes.
    1. Neuroscience

    Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

    Hideo Hagihara, Hirotaka Shoji ... Tsuyoshi Miyakawa
    Brain lactate and pH changes, identified as common features in diverse neuropsychiatric animal models, may represent transdiagnostic endophenotypes associated with cognitive impairment.
    1. Neuroscience

    Open-source tools for behavioral video analysis: Setup, methods, and best practices

    Kevin Luxem, Jennifer J Sun ... Mark Laubach
    Methods for video analysis of behaving animals are described, with guidance provided on setting up the methods in a research laboratory and best practices for experimenters and developers.

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