941 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A putative ATPase mediates RNA transcription and capping in a dsRNA virus

    Xuekui Yu et al.
    Atomic structures suggest a novel mechanism for the regulation of mRNA transcription and capping in dsRNA viruses.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis

    Zhaowei Wang et al.
    A picorna-like virus promotes the accumulation of caspase-cleaved drosophila inhibitor of apoptosis 1 by inducing the degradation of NTAN1, a key N-end rule degradation pathway component, leading to apoptosis inhibition and viral replication enhancement.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Functional proteomic atlas of HIV infection in primary human CD4+ T cells

    Adi Naamati et al.
    Identification and characterisation of proteins and processes regulated by HIV in primary human CD4+ T cells using an HIV reporter virus for one-step, antibody-free magnetic selection.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Viral hijacking of a replicative helicase loader and its implications for helicase loading control and phage replication

    Iris V Hood, James M Berger
    A phage-encoded protein inhibits a bacterial replicative helicase loading factor by exploiting an internal site that auto-regulates loader self-assembly and ATPase activity.
    1. Cell Biology
    2. Immunology and Inflammation

    ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA

    Charlotte Lässig et al.
    Mutations within the ATPase domain of RIG-I in patients with Singleton-Merten Syndrome prevent ATP-hydrolysis dependent dissociation of RIG-I from double-stranded RNA and lead to unintentional constitutive signaling through increased binding of endogenous RNA.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanochemical coupling and bi-phasic force-velocity dependence in the ultra-fast ring ATPase SpoIIIE

    Ninning Liu et al.
    Probing the DNA motor SpoIIIE at the single-molecule level has revealed its force-generating step, rich translocation dynamics during motor operation and a novel, bi-phasic mechanical response to opposing force.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Establishing the role of ATP for the function of the RIG-I innate immune sensor

    David C Rawling et al.
    The immune sensor RIG-I uses ATP-mediated compaction as a signaling trigger and a proofreading mechanism.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants

    Charlotte Lässig et al.
    RIG-I Singleton-Merten syndrome mutations either mimic or freeze the protein in an ATP-bound state and lead to autoimmune signalling through a gain-of-function recognition of self-RNA.
    1. Neuroscience

    Learning speed and detection sensitivity controlled by distinct cortico-fugal neurons in visual cortex

    Sarah Ruediger, Massimo Scanziani
    Neural pathways from mammalian visual cortex to ancestral brain structures control learning speed and performance of a simple detection task.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Early postmortem mapping of SARS-CoV-2 RNA in patients with COVID-19 and the correlation with tissue damage

    Stefanie Deinhardt-Emmer et al.
    Early postmortem autopsy of COVID-19 patients shows high viral loads and damage of the lung, although extrapulmonary cells demonstrate no injury, they contribute to inflammation, hyper-coagulation, and multiple organ dysfunction.

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