Sleep and wake states are not sufficient to drive changes in neocortical synaptic strengths.

OCT4 and SOX2 display partially independent activity to regulate chromatin accessibility, and highly dynamic activity of OCT4 is required throughout the cell cycle to maintain pluripotency enhancer accessibility.

Glutamatergic neurons lacking the mitochondrial pyruvate carrier show reduced M-type potassium channel activity and hyperexcitability upon intense firing.

Inhibition of GOT2 drives growth inhibitory reductive stress that can be rescued by electron acceptors in vitro, whereas GOT2 inhibition in endogenous or transplanted tumor models is tolerated without consequence, highlighting the importance of context when studying tumor metabolism.

Yap and Taz regulate proliferation and differentiation of Schwann cells, driving radial sorting, myelination and myelin maintenance of peripheral nerves.

Optogenetic and electrical low-frequency stimulation in the sclerotic hippocampus prevents the emergence of spontaneous focal and evoked generalized seizures in a mouse epilepsy model.

Single-cell transcriptomics analysis identifies the dynamic activity of transcription factors at the onset of hematopoeitic stem and progenitor cells formation during embryonic development.

Colon cancer cells disseminate and colonize distant organ sites along the invasion-metastasis cascade by transiently activating intermediate epithelial to mesenchymal transition states through distinct transcriptional trajectories.

A novel algorithm, consensus non-negative matrix factorization (cNMF), accurately identifies gene expression programs underlying cell-type identity and cellular activities from single-cell RNA-Seq data.

An epigenomic analysis in mouse macrophages reveals that a highly abundant transposable element exhibits activity as an immune inducible regulatory element.