265 results found
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death

    Laurelle Jackson et al.
    Under conditions where the force of HIV infection per cell is high, partial attenuation of infection with inhibitors can increase the number of live infected cells and may paradoxically be beneficial for viral spread.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Dengue genetic divergence generates within-serotype antigenic variation, but serotypes dominate evolutionary dynamics

    Sidney M Bell et al.
    Each dengue serotype contains moderate antigenic diversity, and population immunity drives clade turnover in a hyperendemic population.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Structure and topology around the cleavage site regulate post-translational cleavage of the HIV-1 gp160 signal peptide

    Erik Lee Snapp et al.
    Signal-peptide cleavage of HIV-1 envelope glycoprotein is delayed because of alpha-helical structure covering the cleavage site, effecting early cleavage alters the folding pathway and resulting in localized misfolding and reduced viral fitness.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Adaptive Evolution: At the mercy of viruses

    Claus O Wilke, Sara L Sawyer
    Insight
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    1. Ecology
    2. Plant Biology

    The Natural History of Model Organisms: Planting molecular functions in an ecological context with Arabidopsis thaliana

    Ute Krämer
    Research in molecular ecology and evolution is increasingly utilizing the model plant Arabidopsis thaliana, placing a spotlight on its natural history.
  1. Point of View: Telling it like it is

    Alison Woollard
    Following a year of public engagement activities associated with the Royal Institution Christmas Lectures, Alison Woollard explains why scientists need to communicate with the public.
    1. Microbiology and Infectious Disease

    Phage Predation: Killing the killers

    Marianne De Paepe, Marie-Agnès Petit
    Insight
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    1. Cell Biology
    2. Ecology

    The Natural History of Model Organisms: From molecular manipulation of domesticated Chlamydomonas reinhardtii to survival in nature

    Severin Sasso et al.
    Dubbed the 'green yeast', the model alga C. reinhardtii has profoundly advanced many areas of biology, but much remains to be learnt about its life in the wild.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Science Forum: Viral factors in influenza pandemic risk assessment

    Marc Lipsitch et al.
    We identify key strengths and limitations in use of viral genotyping and phenotyping to estimate pandemic risk from influenza A viruses, focusing on 3 traits, hemagglutinin binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency.
  2. Point of View: A recipe for mediocrity and disaster, in five axioms

    Henry R Bourne
    Biomedical research in the US will become unsustainable unless scientists and research institutions start to question certain assumptions they have long taken for granted.

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