Enterovirus A71 adaptation to bind heparan sulfate as receptor comes with compensation that destabilizes its virus capsid.

The software package Ais simplifies automated segmentation in cryo-electron tomography, enabling users to segment, detect particles, and visualize data in a streamlined and accessible workflow.

Plasmodium parasites have repurposed the heme oxygenase scaffold from its canonical heme-degrading function to fulfill an essential and adaptive role in gene expression within the apicoplast organelle.

High mutational load tumors mitigate effects from protein-damaging mutations by up-regulating complexes that buffer against misfolding stress, revealing therapeutic vulnerabilities and suggesting disrupted proteostasis is a hallmark of somatic evolution.

Through interactions with viral RNA and NS5, Zika virus changes the composition of the IGF2BP2-containing ribonucleoprotein complex for the benefit of the viral RNA amplification step of its life cycle.