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    1. Structural Biology and Molecular Biophysics

    Structural basis for DNA 5´-end resection by RecJ

    Kaiying Cheng et al.
    A structural investigation reveals details of the mechanism by which the nuclease RecJ processes DNA ends to repair double strand breaks.
    1. Structural Biology and Molecular Biophysics
    2. Human Biology and Medicine

    The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain

    Simon Mysling et al.
    Intravascular triglyceride hydrolysis by lipoprotein lipase is crucial for delivering lipid nutrients to vital tissues, such as the heart, skeletal muscle, and adipose tissue.
    1. Immunology and Inflammation

    The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1+ lymph node macrophages

    Chung Park et al.
    Lymph node gp120 specific B cells extract locally injected HIV-1 gp120 from SIGN-R1 positive macrophages that line the subcapsular sinus overlying the lymph node interfollicular channels.
    1. Epidemiology and Global Health

    Nationally-representative serostudy of dengue in Bangladesh allows generalizable disease burden estimates

    Henrik Salje et al.
    To maximize broad insight on disease burden, seroprevalence studies should be generalizable to the wider population, both in age and location.
    1. Structural Biology and Molecular Biophysics

    Designed α-sheet peptides inhibit amyloid formation by targeting toxic oligomers

    Gene Hopping et al.
    Novel designed alpha-sheet peptides inhibit amyloidosis in two different systems and preferentially bind the toxic oligomer.
    1. Structural Biology and Molecular Biophysics

    An unexpected INAD PDZ tandem-mediated plcβ binding in Drosophila photo receptors

    Fei Ye et al.
    Biochemical and structural studies uncover an unexpected mode of interaction, with unprecedented high affinity, between INAD scaffold and NORPA that is critical for Drosophila compound eye photo-transduction.
    1. Developmental Biology

    Multipotent versus differentiated cell fate selection in the developing Drosophila airways

    Ryo Matsuda et al.
    A genetic framework that balances the numbers of multipotent precursors and differentiated cells in the developing airways of Drosophila is presented.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat

    Ursula Schulze-Gahmen et al.
    Structure-function analysis of the super elongation complex formed when HIV replicates inside cells reveals that the HIV-1 Tat protein binds to a cleft between P-TEFb, an enzyme that is involved in normal transcription, and AFF4, a protein that is used to build the super elongation complex
    1. Stem Cells and Regenerative Medicine

    Myofiber-specific TEAD1 overexpression drives satellite cell hyperplasia and counters pathological effects of dystrophin deficiency

    Sheryl Southard et al.
    For skeletal muscle in mice, the size of the stem cell pool can be uncoupled from overall tissue size allowing for a dramatic increase in stem cell number.
    1. Epidemiology and Global Health

    Ebola virus disease in the Democratic Republic of the Congo, 1976-2014

    Alicia Rosello et al.
    Analysing a compilation of individual-level data gathered across the seven Ebola Virus Disease outbreaks in the Democratic Republic of the Congo reveals factors that contribute to the spread of the disease and mortality.