1,145 results found
    1. Medicine
    2. Microbiology and Infectious Disease

    Non-nucleoside reverse transcriptase inhibitor-based combination antiretroviral therapy is associated with lower cell-associated HIV RNA and DNA levels compared to protease inhibitor-based therapy

    Alexander O Pasternak, Jelmer Vroom ... The Co-morBidity in Relation to Aids (COBRA) Collaboration
    In two independent cohorts, NNRTI-based cART regimens are associated with significantly lower cell-associated HIV RNA levels than PI-based regimens, suggesting more potent suppression of residual virus replication by NNRTI-based regimens.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    A virus-encoded protein suppresses methylation of the viral genome through its interaction with AGO4 in the Cajal body

    Liping Wang, Yi Ding ... Rosa Lozano-Duran
    The Cajal body is essential for plants to deploy antiviral DNA methylation.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Geminivirus-encoded TrAP suppressor inhibits the histone methyltransferase SUVH4/KYP to counter host defense

    Claudia Castillo-González, Xiuying Liu ... Xiuren Zhang
    A viral protein hijacks the key effector of transcriptional gene silencing, Su(var)3-9, to evade host plant surveillance.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis

    Virender Kumar Pal, Ragini Agrawal ... Amit Singh
    A gaseous signaling molecule hydrogen sulfide stimulates mitochondrial bioenergetics, maintains glutathione redox poise, and suppresses ROS to subvert viral rebound in latently infected CD4+ T cells from HIV subjects.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling

    Lukasz Kedzierski, Michelle D Tate ... Sandra E Nicholson
    The intracellular SOCS5 protein has a unique and key role in restraining influenza A infection by regulating epidermal growth factor receptor signaling in airway epithelial cells.
    1. Neuroscience

    Contextual and cross-modality modulation of auditory cortical processing through pulvinar mediated suppression

    Xiao-lin Chou, Qi Fang ... Li I Zhang
    Electrophysiological recording and optogenetic manipulation approaches reveal that a multisensory bottom-up SC-LP-A1 pathway plays a role in contextual and cross-modality modulation of auditory cortical processing.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Design of an optimal combination therapy with broadly neutralizing antibodies to suppress HIV-1

    Colin LaMont, Jakub Otwinowski ... Armita Nourmohammad
    Computational evolutionary model to predict the efficacy of broadly neutralizing antibodies (bNAbs) in suppressing HIV and to design optimal combination therapy with bNAbs.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Plant-virus Interactions: Caught in a TrAP

    Delfina A Ré, Pablo A Manavella
    Version of Record
    Insight
    1. Chromosomes and Gene Expression
    2. Stem Cells and Regenerative Medicine

    MicroRNA-deficient mouse embryonic stem cells acquire a functional interferon response

    Jeroen Witteveldt, Lisanne I Knol, Sara Macias
    MiRNA-mediated suppression of MAVS expression in embryonic stem cells is necessary to inactivate the type I interferon response.
    1. Neuroscience

    Auditory cortex shapes sound responses in the inferior colliculus

    Jennifer M Blackwell, Alexandria MH Lesicko ... Maria N Geffen
    Feedback from the mammalian auditory cortex to the midbrain decreases sound selectivity, altering how sounds are processed in the brain.

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