Alexander O Pasternak, Jelmer Vroom ... The Co-morBidity in Relation to Aids (COBRA) Collaboration
In two independent cohorts, NNRTI-based cART regimens are associated with significantly lower cell-associated HIV RNA levels than PI-based regimens, suggesting more potent suppression of residual virus replication by NNRTI-based regimens.
A gaseous signaling molecule hydrogen sulfide stimulates mitochondrial bioenergetics, maintains glutathione redox poise, and suppresses ROS to subvert viral rebound in latently infected CD4+ T cells from HIV subjects.
Lukasz Kedzierski, Michelle D Tate ... Sandra E Nicholson
The intracellular SOCS5 protein has a unique and key role in restraining influenza A infection by regulating epidermal growth factor receptor signaling in airway epithelial cells.
Electrophysiological recording and optogenetic manipulation approaches reveal that a multisensory bottom-up SC-LP-A1 pathway plays a role in contextual and cross-modality modulation of auditory cortical processing.
Colin LaMont, Jakub Otwinowski ... Armita Nourmohammad
Computational evolutionary model to predict the efficacy of broadly neutralizing antibodies (bNAbs) in suppressing HIV and to design optimal combination therapy with bNAbs.