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Phylogenetic relationships between viral RNA segments are distinct between subtypes and lineages of seasonal human influenza A viruses and implicate RNA-RNA relationships as novel drivers of influenza virus evolution.

ePAC, a novel cancer vaccine utilizing a mammalian-derived virus-like particle to co-deliver neoantigens and CpG-ODN, demonstrates strong antitumor efficacy in mouse models.

Thermodynamic, kinetic, and dynamic analyses as well as solubility proteome profiling reveal that influenza A virus liquid inclusions may be selectively hardened with promising antiviral activity.

Higher-order assembly enables and links pathogen recognition and downstream steps in the TRIM5-mediated anti-HIV response.

Insight into the molecular assembly of a protein with a central role in infections paves the way to understanding how Rift Valley fever virus causes disease.

Duck Hepatitis B core protein forms capsids with a slowly folding extension domain which folding competence is important for viral replication.

Computational and theoretical models reveal mechanisms by which protein compartments assemble around enzymes and reagents to facilitate reactions in bacteria, allowing the identification of strategies for reengineering such compartments as customizable nanoreactors.

Biochemical and instrumental analysis showed that the membrane-induced exposure of myristoyl from the MA protein of Mason-Pfizer monkey virus triggers allosteric conformational changes resulting in MA oligomerization and unfolding of the cleavage site between MA and downstream domains of Gag.

Newly discovered viruses in dead and dying farmed Chinook salmon are widely distributed in threatened wild Chinook and sockeye salmon populations.

The ribosome bound structure of a new IRES reveals novel architecture features used by viruses to hijack cellular translation.