484 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome

    Priyanka D Abeyrathne et al.
    An ensemble of cryo-EM structures reveals how eukaryotic elongation factor 2 positions the first codon of a viral mRNA for translation.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates

    Tijana Ivanovic et al.
    Long-lived intermediate states formed by glycoprotein catalysts are an essential part of the process used by influenza virus particles to infect cells.
    1. Structural Biology and Molecular Biophysics

    How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion

    Luke H Chao et al.
    Single-particle studies of dengue-virus membrane fusion and the effect of small-molecule inhibitors of infection clarify the viral fusion mechanism.
    1. Microbiology and Infectious Disease

    Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL, and NCK1

    Hongbing Jiang et al.
    Genetic and biochemical analyses identify a pathway important for infection by many picornaviruses.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Distinct functional determinants of influenza hemagglutinin-mediated membrane fusion

    Tijana Ivanovic, Stephen C Harrison
    The mechanism of membrane-fusion catalysis in influenza viral infection of target cells is robust against the presence of a large fraction of non-productive viral fusion proteins.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling

    Zane A Jaafar et al.
    The hepatitis C virus IRES binds and remodels preassembled eukaryotic translation preinitiation complexes, using specific initiation factor protein within a "bacterial-like" mode of initiation that can function in both stressed and unstressed cells.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations

    Xiaochu Ma et al.
    The identification of a single-CD4 bound asymmetric HIV-1 Envelope trimer intermediate provides new mechanistic insights into the activation of Envelope for fusion, and highlights the importance of asymmetry in biology.
    1. Microbiology and Infectious Disease

    HIV in Women: How HIV exploits T cells in the endometrium

    Marta Rodriguez-Garcia
    Immune cells in the endometrium are targeted by HIV and re-programmed to allow them to survive and spread the virus throughout the body.
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    1. Genetics and Genomics
    2. Human Biology and Medicine

    Point of View: Bioengineering horizon scan 2020

    Luke Kemp et al.
    20 emerging issues in bioengineering that will have profound impacts on society have been identified.

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