902 results found
    1. Computational and Systems Biology

    Cell-cycle-gated feedback control mediates desensitization to interferon stimulation

    Anusorn Mudla et al.
    Cell cycle gating enables a temporal compartmentalization of negative vs positive feedback control processes, leading to differential responses to repetitive interferon stimulations.
    1. Immunology and Inflammation
    2. Neuroscience

    miRNA profile is altered in a modified EAE mouse model of multiple sclerosis featuring cortical lesions

    Nicola S Orefice et al.
    A novel EAE model featuring cortical lesions and an autoimmune heterogeneity, two key parameters missing in the classical model, allows for insights in disease pathogenesis.
    1. Microbiology and Infectious Disease

    Complement opsonization of HIV affects primary infection of human colorectal mucosa and subsequent activation of T cells

    Pradyot Bhattacharya et al.
    Complement opsonized HIV exposure gives rise to a colorectal mucosal environment with an initial suppressed antiviral response and increased infection of immune cells and altered activation of T cells.
    1. Medicine

    Obesity and diabetes as comorbidities for COVID-19: Underlying mechanisms and the role of viral–bacterial interactions

    Ilja L Kruglikov et al.
    Dysfunctionaladipose tissue puts obese and type 2 diabetic patients at higher risk.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races

    Jeannette L Tenthorey et al.
    Mutations in the TRIM5α retrovirus-binding interface frequently improve but rarely disrupt retroviral restriction.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Erasable labeling of neuronal activity using a reversible calcium marker

    Fern Sha et al.
    Protein engineering of a reversibly switchable fluorescent protein enables post-hoc reversible and repeatable marking of elevated calcium concentrations using blue light.
    1. Neuroscience

    Extensive and spatially variable within-cell-type heterogeneity across the basolateral amygdala

    Timothy P O'Leary et al.
    Basolateral amygdala excitatory neurons are a highly heterogenous collection of neurons that spatially covary in molecular, cellular, and circuit properties.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum

    Russell P Swift et al.
    The pyruvate kinase contained in the apicoplast organelle of malaria parasites makes the nucleotide triphosphates required for several processes including transcription of the organellar genome.
    1. Cancer Biology

    Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer

    Patricia L Theard et al.
    Combined EGFR and SOS1 inhibition synergize to inhibit NSCLC spheroid growth.
    1. Medicine

    Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome

    Simone Bersini et al.
    Direct reprogramming of smooth muscle cells from HGPS patients revealed that BMP4 is a key contributor of vascular degeneration and might represent a new therapeutic target.

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