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    1. Cancer Biology

    STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells

    Jong Wook Kim, Christian Berrios ... William C Hahn
    ST recruitment of STRIPAK facilitates PP2A-mediated dephosphorylation of MAP4K4 and induces cell transformation highlighting that STRIPAK complex plays a key role in defining PP2A specificity and activity.
    1. Ecology
    2. Microbiology and Infectious Disease

    Recurring patterns in bacterioplankton dynamics during coastal spring algae blooms

    Hanno Teeling, Bernhard M Fuchs ... Rudolf I Amann
    Dynamic successive blooms of clades of planktonic marine bacteria that can be observed during blooms of marine algae follow discernible patterns, part of which might be explained by substrate-induced forcing.
    1. Computational and Systems Biology

    Discovering Root Causal Genes with High Throughput Perturbations

    Eric V Strobl, Eric R Gamazon
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Medicine

    Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

    Yanling Huang, Haocong Mo ... Geyang Xu
    Experimental results suggest a previously unknown regulatory mechanism for GLP-1 production in L cells, which could offer new insights into diabetes treatments.
    1. Developmental Biology
    2. Neuroscience

    Synapse weakening-induced caspase-3 activity confers specificity to microglia-mediated synapse elimination

    Zhou Yu, Andrian Gutu ... Erin K O’Shea
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium

    Xiaowen Liu, Thuy Vien ... David E Clapham
    The primary cilia polycystin proteins, polycystin-1 and polycystin-2, affect cilia length in the kidney collecting duct epithelia, but only polycystin-2 is required for the functional ion channel in this organelle.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice

    Clare M Smith, Richard E Baker ... Christopher M Sassetti
    A novel dual genome approach that combines genetically diverse mice and a library of bacterial mutants to define the genome-wide host pathogen interactions that drive distinct outcomes to tuberculosis.
    1. Cancer Biology

    MELK expression correlates with tumor mitotic activity but is not required for cancer growth

    Christopher J Giuliano, Ann Lin ... Jason M Sheltzer
    Cancer cells can grow in vitro and in vivo in the absence of maternal embryonic leucine zipper kinase (MELK).
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    OpenNucleome for high-resolution nuclear structural and dynamical modeling

    Zhuohan Lao, Kartik D Kamat ... Bin Zhang
    An open-source tool for computational simulations of the human genome has been introduced, enabling the characterization of complex nuclear environments and the interpretation of experimental observations.
    1. Neuroscience

    The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells

    Fugui Niu, Peng Han ... Sheng-Jian Ji
    The m6A reader YTHDF2 negatively regulates retinal ganglion cell dendrite branching through destabilizing its m6A-modified target mRNAs which control dendrite development and maintenance, and Ythdf2 conditional knockout in retina improves visual acuity and alleviates acute ocular hypertension-induced glaucoma in mice.