210 results found
    1. Developmental Biology

    Impaired yolk sac NAD metabolism disrupts murine embryogenesis with relevance to human birth defects

    Kayleigh Bozon, Hartmut Cuny ... Sally L Dunwoodie
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Solid
    1. Medicine
    2. Computational and Systems Biology

    Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats

    Hong Yang, Cheng Zhang ... Adil Mardinoglu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Developmental Biology

    Tgfbr1 regulates lateral plate mesoderm and endoderm reorganization during the trunk to tail transition

    Anastasiia Lozovska, Ana Casaca ... Moises Mallo
    Tgfbr1 signaling governs all processes associated with the trunk to tail transition, including the repositioning of neuro-mesodermal progenitors, as well as the remodeling of the lateral plate mesoderm and embryonic endoderm.
    1. Immunology and Inflammation

    The protective roles of eugenol on type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway

    Yalan Jiang, Pingping He ... Xiaoou Shan
    Eugenol has the ability to improve the type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    The Drosophila hematopoietic niche assembles through collective cell migration controlled by neighbor tissues and Slit-Robo signaling

    Kara A Nelson, Kari F Lenhart ... Stephen DiNardo
    A new example of niche formation, revealing the mode of niche cell migration, implicates extrinsic sources of positional information, and uncovers the pathway required for stereotypical positioning of the niche.
    1. Epidemiology and Global Health

    A Sex-specific Mendelian Randomization-Phenome-Wide Association Study of Body Mass Index

    Zhu Liduzi Jiesisibieke, Io Ieong Chan ... C Mary Schooling
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Cell Biology

    Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

    Zewei Zhao, Longyun Hu ... Zhonghan Yang
    ADGRA3 signaling promotes adipose thermogenesis via Gs-PKA-CREB, suggesting hesperetin and ADGRA3 overexpression as obesity therapies.
    1. Cell Biology
    2. Neuroscience

    The effects of 17α-estradiol treatment on endocrine system revealed by single-nucleus transcriptomic sequencing of hypothalamus

    Lei Li, Guanghao Wu ... Yinchuan Li
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Computational and Systems Biology

    Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age

    Dylan C Sarver, Muzna Saqib ... G William Wong
    Mitochondrial respiration atlas reveals functional signatures of aging across diverse tissues and organ systems.
    1. Immunology and Inflammation

    Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity

    Yue Yang, Bin Huang ... Fangfang Zhang
    Mir802 serves as a pivotal mediator facilitating communication between adipose tissue and macrophages through the activation of NF-KB signaling pathways.

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