210 results found
    1. Developmental Biology

    Local cell interactions and self-amplifying individual cell ingression drive amniote gastrulation

    Octavian Voiculescu, Lawrence Bodenstein ... Claudio D Stern
    A combination of two local cell interactions, intercalation and ingression amplified by a community-effect, is sufficient to explain the global movements of amniote gastrulation.
    1. Cell Biology

    Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity

    Dan Wu, Venkateswararao Eeda ... Weidong Wang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology

    Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival

    Marshall Lukacs, Tia Roberts ... Rolf W Stottmann
    Anchoring of proteins to the cell membrane through the glycosylphosphatidylinositol (GPI) anchor is critical for the survival of the cells that will give rise to the brain and face.
    1. Neuroscience

    Neural substrates of cold nociception in Drosophila larva

    Atit A. Patel, Albert Cardona, Daniel N. Cox
    Not revised
    Reviewed Preprint v1
    • Useful
    • Convincing
    • Incomplete
    1. Cell Biology
    2. Neuroscience

    The effects of 17α-estradiol treatment on endocrine system revealed by single-nucleus transcriptomic sequencing of hypothalamus

    Lei Li, Guanghao Wu ... Yinchuan Li
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology

    An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP

    Marc Fiedler, Michael Graeb ... Mariann Bienz
    The Chip/LDB-SSDP complex integrates multiple signals to render TCF/LEF enhancers Wnt responsive.
    1. Developmental Biology
    2. Genetics and Genomics

    Combinatorial chromatin dynamics foster accurate cardiopharyngeal fate choices

    Claudia Racioppi, Keira A Wiechecki, Lionel Christiaen
    ATAC-seq, CRISPR/Cas9 mutagenesis, reporter and gene expression assays revealed dynamic chromatin accessibility profiles governing differential gene expression during heart vs. pharyngeal muscle fate choices in the powerful chordate model Ciona.
    1. Neuroscience

    Exposure to false cardiac feedback alters pain perception and anticipatory cardiac frequency

    Eleonora Parrotta, Patric Bach ... Francesca Ferri
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Pupal behavior emerges from unstructured muscle activity in response to neuromodulation in Drosophila

    Amicia D Elliott, Adama Berndt ... Benjamin H White
    The elementary units of a fruit fly behavioral sequence are described at single-muscle resolution and shown to exhibit variability that is subject to neuromodulatory regulation.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Genome streamlining in a minute herbivore that manipulates its host plant

    Robert Greenhalgh, Wannes Dermauw ... Merijn R Kant
    The genome of a tiny tomato pest reveals mechanisms that underlie metazoan genome reduction.
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