In mammals, the vesicular glutamate transporter 1 acquired a proline-rich sequence that negatively regulates the spontaneous release of glutamate by reducing the exchange of synaptic vesicles along the axon.
The brain continuously updates the learned temporal relationship between motor commands and their associated somatosensory feedback, which determines the perceived intensity and ticklishness of self-touch.
Cellularization in Sphaeroforma arctica generates a self-organized structure that morphologically resembles an epithelium, and is associated with tightly regulated expression of cell adhesion pathways.
Sterol kinetics and cell-based assays reveal a heretofore unknown step in cholesterol trafficking through the endolysosomal compartment, involving a direct functional interaction between NPC2 and lysosbisphosphatidic acid.
Noninvasive stimulation of hippocampal networks increases connectivity in a functionally-specific manner that is highly relevant to effective episodic memory performance that depends on the targeted network.