2,460 results found
    1. Cancer Biology
    2. Cell Biology

    Opto-magnetic capture of individual cells based on visual phenotypes

    Loïc Binan et al.
    Single cells from a large heterogeneous population can be identified, isolated and clonally expanded using commonly available microscopy equipment and simple reagents, based solely on visual characteristics.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes

    Nimisha Chaturvedi et al.
    Integrated analysis of IFN-λ and HCV amino acid variation indicates the key role of host innate immunity in viral control.
    1. Neuroscience

    Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1

    J Elliott Robinson et al.
    Heterozygous Nf1 knockout mice exhibit distinct dopaminergic phenotypes in vivo, as revealed by the genetically encoded dopamine sensor dLight1, patch clamp electrophysiology, optogenetics, and novel viral tools for morphological analysis.
    1. Microbiology and Infectious Disease

    Tropical Diseases: Can CRISPR help in the fight against parasitic worms?

    Paul McVeigh, Aaron G Maule
    The first reports of CRISPR/Cas9 genome editing in flatworms could usher in a new era of research on these dangerous human parasites.
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    1. Ecology
    2. Evolutionary Biology

    The Natural History of Model Organisms: Advancing biology through a deeper understanding of zebrafish ecology and evolution

    David M Parichy
    The zebrafish is a premier model organism for biomedical research, with a rich array of tools and genomic resources, and combining these with a fuller appreciation of wild zebrafish ecology could greatly extend its utility in biological research.
    1. Ecology
    2. Plant Biology

    The Natural History of Model Organisms: Planting molecular functions in an ecological context with Arabidopsis thaliana

    Ute Krämer
    Research in molecular ecology and evolution is increasingly utilizing the model plant Arabidopsis thaliana, placing a spotlight on its natural history.
    1. Microbiology and Infectious Disease

    Research: A comprehensive and quantitative exploration of thousands of viral genomes

    Gita Mahmoudabadi, Rob Phillips
    A compendium of critical genomic numbers for viruses through the lenses of different viral classification systems.
    1. Microbiology and Infectious Disease

    Point of View: What next for gain-of-function research in Europe?

    Robin Fears, Volker ter Meulen
    A EASAC working group on gain-of-function research has emphasised the importance of ensuring that the necessary safeguards and policies are in place.

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